Niu Huixia, Xu Manjin, Tu Pengcheng, Xu Yunfeng, Li Xueqing, Xing Mingluan, Chen Zhijian, Wang Xiaofeng, Lou Xiaoming, Wu Lizhi, Sun Shengzhi
Zhejiang Provincial Center for Disease Control and Prevention, 3399 Bin Sheng Road, Binjiang District, Hangzhou 310051, China.
School of Public Health, Xiamen University, Xiang'an South Road, Xiang'an District, Xiamen 361102, China.
Toxics. 2024 Jan 8;12(1):47. doi: 10.3390/toxics12010047.
Emerging contaminants have been increasingly recognized as critical determinants in global public health outcomes. However, the intricate relationship between these contaminants and glucose metabolism remains to be fully elucidated. The paucity of comprehensive clinical data, coupled with the need for in-depth mechanistic investigations, underscores the urgency to decipher the precise molecular and cellular pathways through which these contaminants potentially mediate the initiation and progression of diabetes mellitus. A profound understanding of the epidemiological impact of these emerging contaminants, as well as the elucidation of the underlying mechanistic pathways, is indispensable for the formulation of evidence-based policy and preventive interventions. This review systematically aggregates contemporary findings from epidemiological investigations and delves into the mechanistic correlates that tether exposure to emerging contaminants, including endocrine disruptors, perfluorinated compounds, microplastics, and antibiotics, to glycemic dysregulation. A nuanced exploration is undertaken focusing on potential dietary sources and the consequential role of the gut microbiome in their toxic effects. This review endeavors to provide a foundational reference for future investigations into the complex interplay between emerging contaminants and diabetes mellitus.
新型污染物已日益被视为全球公共卫生结果的关键决定因素。然而，这些污染物与葡萄糖代谢之间的复杂关系仍有待充分阐明。综合临床数据的匮乏，加上深入进行机制研究的必要性，凸显了迫切需要破译这些污染物可能介导糖尿病发生和发展的精确分子和细胞途径。深入了解这些新型污染物的流行病学影响以及阐明潜在的机制途径，对于制定基于证据的政策和预防干预措施至关重要。本综述系统地汇总了流行病学调查的当代研究结果，并深入探讨了将接触新型污染物（包括内分泌干扰物、全氟化合物、微塑料和抗生素）与血糖失调联系起来的机制关联。我们进行了细致入微的探索，重点关注潜在的饮食来源以及肠道微生物群在其毒性作用中的相应作用。本综述旨在为未来对新型污染物与糖尿病之间复杂相互作用的研究提供基础参考。
