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Stanford 型 B 主动脉夹层慢性期的外科治疗。

Surgical treatment in the chronic phase for uncomplicated Stanford type B aortic dissection.

机构信息

Department of Cardiovascular Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.

Department of Cardiovascular Surgery, Seikeikai Chiba Medical Center, Chiba, Japan.

出版信息

PLoS One. 2024 Feb 23;19(2):e0298644. doi: 10.1371/journal.pone.0298644. eCollection 2024.

Abstract

BACKGROUND

The most appropriate surgical method for patients with uncomplicated type B aortic dissection (UTBAD) in the chronic phase remains controversial. This study evaluated the outcomes of patients with UTBAD who needed aortic treatment as well as the impact of the treatment method or indication criteria on their prognosis.

METHODS

This retrospective review of 106 consecutive patients with aortic events in the chronic phase who underwent initial treatment for UTBAD between 2004 and 2021 comprised three groups: 19 patients who underwent endovascular repair (TEVAR), 38 who underwent open aortic repair and the medication group that included 49 patients. Aortic events were defined as a late operation or indication for operation for dissected aorta, aortic diameter (AD) ≥ 55 mm, rapid aortic enlargement (≥5 mm/6 months), and saccular aneurysmal change. The endpoint was all-cause death. We assessed the association between treatment methods or surgical indication criteria and mortality using a Cox regression analysis.

RESULTS

The 5-year actuarial mortality rates were 27.1% in the TEVAR group, 19.6% in the open aortic repair group, and 38.4% in the medication group (p = 0.86). Moreover, the 5-year actuarial mortality rates in patients who had AD ≥ 55 mm were significantly higher than those patients with other surgical indication criteria (41.2% vs. 18.7%, p < 0.01). Multivariable analysis revealed a significant difference in AD ≥ 55 mm (hazard ratio [HR]: 2.88, 95% confidence interval [CI] 1.38-6.02, p < 0.01) and age (HR: 1.09, 95% CI 1.05-1.13, p < 0.01).

CONCLUSIONS

Under the existing surgical indication criteria, there was no difference in mortality rates among patients with UTBAD based on their surgical treatment.

摘要

背景

慢性期非复杂性 B 型主动脉夹层(UTBAD)患者最合适的手术方法仍存在争议。本研究评估了需要主动脉治疗的 UTBAD 患者的结局,以及治疗方法或适应证标准对其预后的影响。

方法

本回顾性研究纳入了 2004 年至 2021 年间因 UTBAD 接受初始治疗的 106 例慢性期主动脉事件患者,包括 19 例行血管内修复术(TEVAR)的患者、38 例行开放主动脉修复术的患者和 49 例药物治疗组患者。主动脉事件定义为夹层主动脉的晚期手术或手术适应证、主动脉直径(AD)≥55mm、主动脉快速扩大(≥5mm/6 个月)和囊状动脉瘤样改变。终点是全因死亡。我们使用 Cox 回归分析评估了治疗方法或手术适应证标准与死亡率之间的关系。

结果

TEVAR 组、开放主动脉修复组和药物治疗组的 5 年生存率分别为 27.1%、19.6%和 38.4%(p=0.86)。此外,AD≥55mm 的患者 5 年生存率明显高于其他手术适应证标准的患者(41.2% vs. 18.7%,p<0.01)。多变量分析显示 AD≥55mm(危险比[HR]:2.88,95%置信区间[CI]:1.38-6.02,p<0.01)和年龄(HR:1.09,95%CI:1.05-1.13,p<0.01)是显著差异的因素。

结论

在现有的手术适应证标准下,根据手术治疗方法,UTBAD 患者的死亡率没有差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa10/10890721/467660f8cc6b/pone.0298644.g001.jpg

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