Institut MICALIS, INRAE, AgroParisTech, Equipe Bactéries Pathogènes et Santé, Faculté de Pharmacie, Université Paris-Saclay, 91400 Orsay, France.
Matériaux et Santé, Faculté de pharmacie, Université Paris Saclay, 91400 Orsay, France.
Int J Mol Sci. 2024 Feb 12;25(4):2202. doi: 10.3390/ijms25042202.
is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors. But the dysbiosis of the intestinal microbiota creating the conditions for the colonization appears to be fundamental for our understanding of the disease. Colonization implies several steps for the bacteria that do or do not use their capacity of motility with the synthesis of flagella. In this review, we focus on the current understanding of different topics on the flagellum, ranging from its genetic organization to the vaccinal interest in it.
是人类的一种重要病原体,在医院感染中处于领先地位,但在社区中也越来越常见。我们对病理学的认识历史上一直集中在细菌产生的毒素上,这些毒素仍然是其主要的毒力因素。但是,肠道微生物菌群的失调为细菌的定植创造了条件,这似乎是我们理解这种疾病的基础。定植意味着细菌要经历几个步骤,无论它们是否利用了它们的运动能力和鞭毛的合成。在这篇综述中,我们重点介绍了对鞭毛的不同主题的当前理解,范围从其遗传组织到疫苗接种的兴趣。