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来自黄芪甲苷：一种靶向IGFR/CD38的新型抗衰老和抗氧化剂。

Astragalin from : A Novel Anti-Aging and Antioxidant Agent Targeting IGFR/CD38/.

作者信息

Wang Ruifeng, Ding Anping, Wang Jiaye, Wang Jiaxue, Zhou Yujie, Chen Miao, Ju Shuang, Tan Mingpu, Xiang Zengxu

机构信息

College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China.

College of Pharmacy, Nanjing Medical University, Nanjing 211166, China.

出版信息

Antioxidants (Basel). 2024 Jul 18;13(7):859. doi: 10.3390/antiox13070859.

DOI:10.3390/antiox13070859
PMID:39061927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273813/
Abstract

Astragalin (AG), a typical flavonoid found in Turcz (), is abundant in various edible plants and possesses high nutritional value, as well as antioxidant and antibacterial effects. In this study, we initially predicted the mechanism of action of AG with two anti-aging and antioxidant-related protein targets (CD38 and IGFR) by molecular docking and molecular dynamics simulation techniques. Subsequently, we examined the anti-aging effects of AG in (), the antioxidant effects in zebrafish, and verified the related molecular mechanisms. In , AG synergistically extended the lifespan of by up-regulating the expression of through inhibiting the expression of and also activating the AMPK and MAPK pathways to up-regulate the expression of , , and . In oxidatively damaged zebrafish embryos, AG demonstrated a synergistic effect in augmenting the resistance of zebrafish embryos to oxidative stress by up-regulating the expression levels of and within the zebrafish embryos system via the suppression of CD38 enzymatic activity and then inhibiting the expression of through high levels of . These findings highlight the antioxidant and anti-aging properties of AG and indicate its potential application as a supplementary ingredient in aquaculture for enhancing fish health and growth.

摘要

黄芪苷（AG）是一种在地锦草中发现的典型黄酮类化合物，在各种可食用植物中含量丰富，具有很高的营养价值，以及抗氧化和抗菌作用。在本研究中，我们最初通过分子对接和分子动力学模拟技术，预测了AG与两个抗衰老和抗氧化相关蛋白靶点（CD38和IGFR）的作用机制。随后，我们研究了AG在秀丽隐杆线虫中的抗衰老作用、在斑马鱼中的抗氧化作用，并验证了相关分子机制。在秀丽隐杆线虫中，AG通过抑制sir-2.1的表达并激活AMPK和MAPK途径，上调hsp-16.2、hsp-12.6和daf-16的表达，协同延长了其寿命。在氧化损伤的斑马鱼胚胎中，AG通过抑制CD38酶活性，上调斑马鱼胚胎系统内sod-1和cat的表达水平，进而通过高水平的sir-2.1抑制p53的表达，在增强斑马鱼胚胎对氧化应激的抗性方面表现出协同作用。这些发现突出了AG的抗氧化和抗衰老特性，并表明其作为水产养殖中的补充成分，在促进鱼类健康和生长方面的潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/e63cbd3f41dc/antioxidants-13-00859-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/52141a0c70b5/antioxidants-13-00859-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/16a261b74a56/antioxidants-13-00859-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/da74ac321ac3/antioxidants-13-00859-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/b2b704f82436/antioxidants-13-00859-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/02828f1f1e4e/antioxidants-13-00859-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/74b36f1b5cc6/antioxidants-13-00859-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/e63cbd3f41dc/antioxidants-13-00859-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/8c0e81f56476/antioxidants-13-00859-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/85a3d74475ec/antioxidants-13-00859-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/94e157eadd69/antioxidants-13-00859-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/3940ba75bef7/antioxidants-13-00859-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/c0d2856125cc/antioxidants-13-00859-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/419e1aad4048/antioxidants-13-00859-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/52141a0c70b5/antioxidants-13-00859-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/16a261b74a56/antioxidants-13-00859-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/da74ac321ac3/antioxidants-13-00859-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/b2b704f82436/antioxidants-13-00859-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/02828f1f1e4e/antioxidants-13-00859-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/74b36f1b5cc6/antioxidants-13-00859-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3ef/11273813/e63cbd3f41dc/antioxidants-13-00859-g013.jpg

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