Chemistry Department, College of Science, Taibah University, Al-Madinah Al-Munawarah 42353, Saudi Arabia.
The National Organization for Drug Control and Research, Giza 12622, Egypt.
Molecules. 2024 Feb 12;29(4):828. doi: 10.3390/molecules29040828.
A composite of chitosan-supported ZnO nanoparticles (ZnO/CS) was green-synthesized via an easy and cost-effective method using Chicory () plant extract. The synthesis was confirmed using uv-vis spectrometry at a λ of 380 nm, and the surface of the material was characterized via FT-IR spectroscopy, and finally via SEM, which confirmed the distribution of ZnO nanoparticles on the surface of chitosan biopolymer (CS). The synthesized material was applied in the adsorptive removal of residues of the pyridoxine hydrochloride (vitamin B6) pharmaceutical drug from aqueous media using the batch technique. The material's removal capacity was studied through several adjustable parameters including pH, contact time, the dose of the adsorbent, and the capacity for drug adsorption under the optimal conditions. Langmuir and Freundlich isotherms were applied to describe the adsorption process. The removal was found to obey the Freundlich model, which refers to a chemisorption process. Different kinetic models were also studied for the removal process and showed that the pseudo-second-order model was more fitted, which indicates that the removal was a chemisorption process. Thermodynamic studies were also carried out. The maximum removal of vitamin B6 by the nano-ZnO/CS composite was found to be 75% at optimal conditions. The results were compared to other reported adsorbents. Reusability tests showed that the nano-ZnO/CS composite can be efficiently reused up to seven times for the removal of PDX drugs from aqueous media.
壳聚糖负载氧化锌纳米粒子（ZnO/CS）复合材料通过使用菊苣（）植物提取物的简单且经济有效的方法绿色合成。通过在 380nm 处的紫外-可见光谱法确认了合成，并且通过傅里叶变换红外光谱法（FT-IR）和最终通过 SEM 对材料的表面进行了特征化，SEM 确认了氧化锌纳米粒子在壳聚糖生物聚合物（CS）表面的分布。使用分批技术，将合成的材料应用于从水介质中吸附去除盐酸吡哆醇（维生素 B6）药物的残留。通过调节多个参数研究了材料的去除能力，包括 pH、接触时间、吸附剂剂量和最佳条件下的药物吸附容量。应用 Langmuir 和 Freundlich 等温线来描述吸附过程。去除被发现遵循 Freundlich 模型，这表明是化学吸附过程。还研究了不同的动力学模型以用于去除过程，结果表明伪二阶模型更适合，这表明去除是化学吸附过程。还进行了热力学研究。在最佳条件下，纳米 ZnO/CS 复合材料对维生素 B6 的最大去除率为 75%。将结果与其他报道的吸附剂进行了比较。可重复使用性测试表明，纳米 ZnO/CS 复合材料可在从水介质中去除 PDX 药物方面有效重复使用多达七次。
