4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic.
Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic.
Nutrients. 2024 Feb 8;16(4):485. doi: 10.3390/nu16040485.
(1) Objectives Intestinal failure in home parenteral nutrition patients (HPNPs) results in oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to various lipid emulsions influences antioxidant status and liver function markers in HPNPs. (2) Methods: Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. Then, the patients were randomized to subsequently receive Lipoplus and ClinOleic for 6 weeks or vice versa plus 4 weeks of Omegaven after each cycle in a crossover design. Twelve age- and sex-matched healthy controls (HCs) were included. (3) Results: Superoxide dismutase (SOD1) activity and oxidized-low-density lipoprotein concentration were higher in all baseline HPN regimens compared to HCs. The Omegaven lowered SOD1 compared to baseline regimens and thus normalized it toward HCs. Lower paraoxonase 1 activity and fibroblast growth factor 19 (FGF19) concentration and, on the converse, higher alkaline phosphatase activity and cholesten concentration were observed in all baseline regimens compared to HCs. A close correlation was observed between FGF19 and SOD1 in baseline regimens. (4) Conclusions: An escalated dose of FO normalized SOD1 activity in HPNPs toward that of HCs. Bile acid metabolism was altered in HPNPs without signs of significant cholestasis and not affected by Omegaven.
(1) 目的：肠衰竭患者在接受家庭肠外营养（HPNP）时会产生氧化应激和肝损伤。本研究旨在探讨高剂量鱼油（FO）添加到不同脂肪乳剂中如何影响 HPNP 的抗氧化状态和肝功能标志物。(2) 方法：12 名接受 Smoflipid 治疗至少 3 个月的 HPNP 患者接受 FO（Omegaven）治疗 4 周。然后，患者随机分为接受 Lipoplus 和 ClinOleic 治疗 6 周或反之亦然，每个周期后交叉设计加用 4 周 Omegaven。纳入 12 名年龄和性别匹配的健康对照（HC）。(3) 结果：与 HCs 相比，所有基线 HPN 方案中的超氧化物歧化酶（SOD1）活性和氧化型低密度脂蛋白浓度均升高。与基线方案相比，Omegaven 降低了 SOD1，使其向 HCs 正常化。与 HCs 相比，所有基线方案中的对氧磷酶 1 活性和成纤维细胞生长因子 19（FGF19）浓度降低，而碱性磷酸酶活性和胆甾醇浓度升高。在基线方案中观察到 FGF19 和 SOD1 之间存在密切相关性。(4) 结论：FO 的递增剂量使 HPNP 中的 SOD1 活性向 HCs 正常化。尽管没有明显的胆汁淤积迹象，但 HPNP 中的胆汁酸代谢发生了改变，而 Omegaven 没有影响。
