Aston Institute of Photonic Technologies, Aston University, Birmingham B4 7ET, UK.
College of Electronic and Optical Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, China.
Sensors (Basel). 2024 Feb 15;24(4):1247. doi: 10.3390/s24041247.
In this article, we demonstrate an improved efficient fibre sensor with a high sensitivity to measure glucose concentrations in the physiological range of human beings, operating in a broad spectral bandwidth from the near- to mid-infrared. The sensor consists of a dual-peak long period grating (DPLPG) with a period of 150 μm inscribed in an optical fibre with a diameter of 80 μm. The investigation of sensing for refractive index results in a sensitivity of ~-885.7 nm/refractive index unit (RIU) and ~2008.6 nm/RIU in the range of 1.30-1.44. The glucose measurement is achieved by the immobilisation of a layer of enzyme of glucose oxidase (GOD) onto the fibre surface for the selective enhancement of sensitivity for glucose. The sensor can measure glucose concentrations with a maximum sensitivity of -36.25 nm/(mg/mL) in the range of 0.1-3.0 mg/mL. To the best of our knowledge, this is the highest sensitivity ever achieved for a measurement of glucose with a long period grating-based sensor, indicating its potential for many applications including pharmaceutical, biomedical and food industries.
在本文中，我们展示了一种改进的高效光纤传感器，该传感器具有高灵敏度，可在人类生理范围内测量葡萄糖浓度，其工作光谱带宽从近红外到中红外。该传感器由一个双峰值长周期光栅 (DPLPG) 组成，其周期为 150μm，刻写在直径为 80μm 的光纤中。对折射率传感的研究结果表明，在 1.30-1.44 的范围内，灵敏度约为-885.7nm/折射率单位 (RIU) 和~2008.6nm/RIU。通过将葡萄糖氧化酶 (GOD) 的酶层固定在光纤表面上，可以实现葡萄糖的测量，从而选择性地提高对葡萄糖的灵敏度。该传感器可在 0.1-3.0mg/mL 的范围内测量葡萄糖浓度，最大灵敏度为-36.25nm/(mg/mL)。据我们所知，这是基于长周期光栅传感器测量葡萄糖的最高灵敏度，表明其在制药、生物医学和食品工业等许多应用中具有潜力。
