Faber J, Zaides S, Kuperman O, Jacobsohn W Z, Weil S, Freier S
Isr J Med Sci. 1985 Jul;21(7):575-8.
A recently described in vitro test for cow's milk protein hypersensitivity was applied to adult patients with ulcerative colitis. The test system involved the culture of their peripheral blood lymphocytes with and without beta-lactoglobulin, and the results were expressed as a stimulation index. Stimulation with beta-lactoglobulin was significantly higher (P less than 0.02) in patients with active disease than in those with inactive disease or in healthy controls. beta-Lactoglobulin was the only one of four cow's milk proteins that showed this effect. It is concluded that the cow's milk protein beta-lactoglobulin has a specific blastogenic effect on the lymphocytes of patients with active ulcerative colitis, and, therefore, may serve as a marker of disease activity.
一种最近描述的用于检测牛奶蛋白过敏的体外试验应用于成年溃疡性结肠炎患者。该试验系统包括在有和没有β-乳球蛋白的情况下培养他们的外周血淋巴细胞，结果以刺激指数表示。与病情不活跃的患者或健康对照相比，β-乳球蛋白刺激在活动期疾病患者中显著更高（P小于0.02）。β-乳球蛋白是四种牛奶蛋白中唯一显示出这种效应的蛋白。结论是，牛奶蛋白β-乳球蛋白对活动期溃疡性结肠炎患者的淋巴细胞具有特异性的促有丝分裂作用，因此可能作为疾病活动的标志物。
