将Lap-1定位到大鼠（褐家鼠）的连锁群I上。

Assignment of Lap-1 to linkage group I of the rat (Rattus norvegicus).

作者信息

van Zutphen L F, den Bieman M, Hedrich H J, Kluge R

出版信息

Biochem Genet. 1985 Aug;23(7-8):599-606. doi: 10.1007/BF00504294.

Abstract

Genetic analysis of backcross progeny from previously characterized rat inbred strains revealed that the biochemical marker Lap-1 is localized in linkage group I (LG I). Lap-1 codes for leucine arylaminopeptidase (EC 3.4.11). The distances of Lap-1 to c, RT6, and Hbb, based on recombination frequencies, are 3.1 +/- 1.5, 8.3 +/- 4.0, and 11.4 +/- 2.8 cM, respectively. Acon-1 codes for aconitase (EC 4.2.1.3). The calculated distances of Acon-1 to c and Hbb are 30.1 +/- 5.0 and 36.1 +/- 5.3 cM, respectively. This suggests that Acon-1 is also in LG I, but the observed high frequency of double crossovers requires further confirmation of this linkage. Ahd-2, Es-6, and Gdc-1 are linked neither to markers of LG I nor to one another.

摘要

对先前已鉴定的大鼠近交系回交后代进行的遗传分析表明，生化标记Lap-1定位于连锁群I（LG I）。Lap-1编码亮氨酸芳基氨肽酶（EC 3.4.11）。根据重组频率，Lap-1与c、RT6和Hbb的距离分别为3.1±1.5、8.3±4.0和11.4±2.8厘摩。Acon-1编码乌头酸酶（EC 4.2.1.3）。计算得出Acon-1与c和Hbb的距离分别为30.1±5.0和36.1±5.3厘摩。这表明Acon-1也在LG I中，但观察到的高双交换频率需要对这种连锁关系进行进一步确认。Ahd-2、Es-6和Gdc-1既不与LG I的标记连锁，彼此之间也不连锁。