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大鼠近交系中酯酶7和酯酶8的新多态性:组织表达及连锁研究。

New polymorphisms of esterase 7 and esterase 8 in inbred strains of rats: tissue expression and linkage studies.

作者信息

Matsumoto K

出版信息

Biochem Genet. 1980 Oct;18(9-10):879-87. doi: 10.1007/BF00500121.

DOI:10.1007/BF00500121
PMID:7225084
Abstract

Two new esterase polymorphisms (Es-7 and Es-8) were identified in the testis homogenate of laboratory rats, Rattus norvegicus, by using discontinuous gradient polyacrylamide gel electrophoresis. Es-7 expressed two phenotypes: ES-7A (fast) and ES-7B (slow). Es-8, which migrated in the cathodal region rather than the ES-7 region, also expressed two phenotypes: ES-8A (fast) and ES-8B (slow). Linkage tests among Es-2, Es-7, and Es-8 were made from backcross progeny of the mating (LEJ/Hkm x T/Hok)F1 x LEJ/Hkm. One recombinant in 51 progeny tested was observed between Es-2 and Es-7; however, recombination between Es-2 and Es-8 was not observed in the same progeny. In addition, we show that the esterase polymorphisms of Es-5 in liver homogenate and Es-3 in small intestine homogenate are identical.

摘要

通过使用不连续梯度聚丙烯酰胺凝胶电泳,在实验大鼠褐家鼠的睾丸匀浆中鉴定出两种新的酯酶多态性(Es-7和Es-8)。Es-7表现出两种表型:ES-7A(快)和ES-7B(慢)。Es-8在阴极区域而非Es-7区域迁移,也表现出两种表型:ES-8A(快)和ES-8B(慢)。从交配组合(LEJ/Hkm×T/Hok)F1×LEJ/Hkm的回交后代中进行Es-2、Es-7和Es-8之间的连锁测试。在51个测试后代中,观察到Es-2和Es-7之间有一个重组体;然而,在同一后代中未观察到Es-2和Es-8之间的重组。此外,我们表明肝匀浆中的Es-5和小肠匀浆中的Es-3的酯酶多态性是相同的。

相似文献

1
New polymorphisms of esterase 7 and esterase 8 in inbred strains of rats: tissue expression and linkage studies.大鼠近交系中酯酶7和酯酶8的新多态性:组织表达及连锁研究。
Biochem Genet. 1980 Oct;18(9-10):879-87. doi: 10.1007/BF00500121.
2
Biochemical genetics of Es-14 (formerly Es-Si) and a new esterase variation, Es-15, of the laboratory rat (Rattus norvegicus): biochemistry, tissue expression, and linkage to Es-1 in linkage group V.实验大鼠(褐家鼠)Es-14(原Es-Si)的生化遗传学及一种新的酯酶变异体Es-15:生物化学、组织表达以及与第五连锁群中Es-1的连锁关系
Biochem Genet. 1987 Feb;25(1-2):79-93. doi: 10.1007/BF00498953.
3
Serum esterase genetics: identification and hormone induction of the Es-1b esterase in inbred rats.血清酯酶遗传学:近交系大鼠中Es-1b酯酶的鉴定及激素诱导
Biochem Genet. 1979 Dec;17(11-12):1121-9. doi: 10.1007/BF00504349.
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Linkage analyses among five esterase loci in the laboratory rat (Rattus norvegicus).实验大鼠(褐家鼠)五个酯酶基因座的连锁分析。
Biochem Genet. 1980 Jun;18(5-6):433-8. doi: 10.1007/BF00484392.
5
Electrophoretic protein variants in inbred strains of Rattus norvegicus: strain distribution, description of a new esterase polymorphism, and linkage studies.褐家鼠近交系中的电泳蛋白质变体:品系分布、一种新的酯酶多态性描述及连锁研究。
Transplant Proc. 1979 Sep;11(3):1653-6.
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[A new esterase locus, Es-19, in the rat].[大鼠中的一个新酯酶基因座,Es-19]
Jikken Dobutsu. 1992 Apr;41(2):235-7.
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The genetics of esterase 12 and esterase 13 polymorphisms in the Norway rat.褐家鼠酯酶12和酯酶13多态性的遗传学
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Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus.哺乳动物中的常染色体比较连锁:小家鼠和褐家鼠酯酶的遗传学
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Genetic variation and biochemical properties of esterase-18 (ES-18) in the laboratory rat (Rattus norvegicus): a new locus of esterase cluster 2 in linkage group V.实验大鼠(褐家鼠)中酯酶-18(ES-18)的遗传变异和生化特性:V连锁群中酯酶簇2的一个新基因座
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Mapping of the Es-4 locus and linear order of esterase genes (linkage group V; LGV) in the rat.大鼠中Es-4基因座的定位及酯酶基因的线性排列(连锁群V;LGV)
Biochem Genet. 1989 Dec;27(11-12):641-6. doi: 10.1007/BF02396056.

引用本文的文献

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A rat genetic linkage map and comparative maps for mouse or human homologous rat genes.一张大鼠遗传连锁图谱以及小鼠或人类同源大鼠基因的比较图谱。
Mamm Genome. 1994 Feb;5(2):63-83. doi: 10.1007/BF00292332.
2
Nonspecific esterases of Mus musculus.小家鼠的非特异性酯酶
Biochem Genet. 1982 Jun;20(5-6):585-606. doi: 10.1007/BF00484706.
3
A new genetic variation of the malate dehydrogenase-like enzyme (MDL-1) in inbred rats and its possible linkage.近交系大鼠中苹果酸脱氢酶样酶(MDL-1)的一种新的基因变异及其可能的连锁关系。

本文引用的文献

1
Zymogram analyses of various organs from spontaneously hypertensive rats. A genetico-biochemical study.自发性高血压大鼠各器官的酶谱分析。一项遗传生化研究。
Lab Invest. 1970 Mar;22(3):206-11.
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Genetic control of the major electrophoretic component of rat plasma esterase.大鼠血浆酯酶主要电泳成分的遗传控制
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Evidence for linkage between four esterase loci in the rat (Rattus norvegicus).大鼠(褐家鼠)四个酯酶基因座之间连锁的证据。
Biochem Genet. 1982 Jun;20(5-6):443-8. doi: 10.1007/BF00484695.
4
Es-6, a further polymorphic esterase in the rat.Es-6,大鼠体内的另一种多态性酯酶。
Biochem Genet. 1982 Apr;20(3-4):221-8. doi: 10.1007/BF00484420.
5
Biochemical markers in inbred strains of the rat (Rattus norvegicus).大鼠(褐家鼠)近交系中的生化标志物。
Immunogenetics. 1984;19(3):257-66. doi: 10.1007/BF00364769.
6
Nonspecific esterases of mammalian testis. Comparative studies on the mouse (Mus musculus) and rat (rattus norvegicus).哺乳动物睾丸的非特异性酯酶。小鼠(小家鼠)和大鼠(褐家鼠)的比较研究。
Histochemistry. 1985;82(6):547-55. doi: 10.1007/BF00489976.
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Genetic linkage in the Norway rat.褐家鼠的基因连锁
Genetica. 1987 Oct 15;74(2):137-42. doi: 10.1007/BF00055225.
8
Esterase-16 (ES-16) of the rat (Rattus norvegicus): identification and genetic characterization.大鼠(褐家鼠)的酯酶-16(ES-16):鉴定与遗传特征分析。
Biochem Genet. 1988 Oct;26(9-10):605-15. doi: 10.1007/BF02399605.
9
Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats.近交系大鼠生长激素基因的新型限制性片段长度多态性
Biochem Genet. 1989 Oct;27(9-10):591-602. doi: 10.1007/BF02396154.
10
Restriction fragment length polymorphisms detected in N-ras-related sequences of rats and their linkage analyses.在大鼠N-ras相关序列中检测到的限制性片段长度多态性及其连锁分析。
Biochem Genet. 1990 Dec;28(11-12):631-42. doi: 10.1007/BF00553955.
Biochem Genet. 1973 Jun;9(2):109-15. doi: 10.1007/BF00487441.
4
Biochemical genetics of rat esterases: polymorphism, tissue expression, and linkage of four loci.大鼠酯酶的生化遗传学:四个基因座的多态性、组织表达及连锁关系
Biochem Genet. 1973 May;9(1):13-24. doi: 10.1007/BF00485587.
5
Biochemical polymorphism in the rat, Rattus norvegicus: genetic study of four markers.褐家鼠(Rattus norvegicus)的生化多态性:四种标记物的遗传学研究
Biochem Genet. 1973 Mar;8(3):321-8. doi: 10.1007/BF00486185.
6
Genetic control of an esterase of digestive tract tissues in Rattus norvegicus.褐家鼠消化道组织酯酶的遗传控制
Experientia. 1972 Nov 15;28(11):1372. doi: 10.1007/BF01965352.
7
Serum esterase genetics in rats: two new alleles at Es-2, a new esterase regulated by hormonal factors, and linkage of these loci to the Ag-C blood group locus.大鼠血清酯酶遗传学:Es-2 位点的两个新等位基因、一种受激素因素调节的新酯酶,以及这些位点与 Ag-C 血型位点的连锁关系。
Biochem Genet. 1973 Nov;10(3):207-17. doi: 10.1007/BF00485699.
8
Alleles of the second plasma esterase locus in the laboratory rat and their distribution among some inbred strains.实验大鼠中第二个血浆酯酶基因座的等位基因及其在一些近交系中的分布。
Folia Biol (Praha). 1974;20(5):350-3.
9
Screening of inbred rat strains for electrophoretic protein polymorphisms.对近交系大鼠品系进行电泳蛋白质多态性筛选。
Biochem Genet. 1978 Jun;16(5-6):387-98. doi: 10.1007/BF00484206.
10
Serum esterase genetics: identification and hormone induction of the Es-1b esterase in inbred rats.血清酯酶遗传学:近交系大鼠中Es-1b酯酶的鉴定及激素诱导
Biochem Genet. 1979 Dec;17(11-12):1121-9. doi: 10.1007/BF00504349.