实验大鼠中一种酸性磷酸酶（Acp - 2）的遗传变异：与小鼠AP - 1和人类ACP2的可能同源性。
Genetic variation of an acid phosphatase (Acp-2) in the laboratory rat: possible homology with mouse AP-1 and human ACP2.
作者信息
Bender K, Bissbort S, Kuhn A, Nagel M, Günther E
出版信息
Biochem Genet. 1986 Feb;24(1-2):1-11. doi: 10.1007/BF00502974.
A genetic locus controlling the electrophoretic mobility of an acid phosphatase in the rat (Rattus norvegicus) is described. The locus, designed Acp-2, is not expressed in erythrocytes but is expressed in all other tissues studied. The product of Acp-2 hydrolyzes a wide variety of phosphate monoesters and is inhibited by L(+)-tartaric acid. Inbred rat strains have fixed either allele Acp-2a or allele Acp-2b. Codominant expression is observed in the respective F1 hybrids. Backcross progenies revealed the expected 1:1 segregation ratio. Possible loose linkage was found between the Acp-2 and the Pep-3 gene loci at a recombination frequency of 0.36 +/- 0.06.
本文描述了一个控制大鼠（褐家鼠）酸性磷酸酶电泳迁移率的基因位点。该基因位点命名为Acp-2，在红细胞中不表达，但在所研究的所有其他组织中均有表达。Acp-2的产物能水解多种磷酸单酯，并受到L(+)-酒石酸的抑制。近交系大鼠品系已固定了等位基因Acp-2a或等位基因Acp-2b。在相应的F1杂种中观察到共显性表达。回交后代显示出预期的1:1分离比。在Acp-2和Pep-3基因位点之间发现了可能的松散连锁，重组频率为0.36±0.06。
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