Mamontov Oleg V, Zaytsev Valeriy V, Kamshilin Alexei A
Laboratory of New Functional Materials for Photonics, Institute of Automation and Control Processes of Far East Branch of the Russian Academy of Sciences, 690041 Vladivostok, Russia.
Department of Circulation Physiology, Almazov National Medical Research Centre, 197341 St. Petersburg, Russia.
Biomed Opt Express. 2024 Jan 8;15(2):687-699. doi: 10.1364/BOE.511925. eCollection 2024 Feb 1.
Sympathetic vasomotor response is the most important part of the autonomic regulation of circulation, which determines the quality of life. It is disrupted in a number of diseases, particularly in patients with congestive heart failure (CHF). However, experimental evaluation of reflex vasoconstriction is still a non-trivial task due to the limited set of available technologies. The aim of this study is to assess the dynamics of vasomotor response of forearm vessels due to both the deactivation of cardiopulmonary baroreceptors and cold stress using a newly designed imaging plethysmograph (IPG) and compare its performance with classical air plethysmograph (APG). In both vasoconstriction tests, vasomotor response was assessed as a change in the blood flow rate due to venous occlusion compared to that at rest. Both tests were carried out in 45 CHF patients both before and after heart transplantation, as well as in 11 age-matched healthy volunteers. Prior to transplantation, both APG and IPG showed a significant decrease in vasomotor response in CHF patients due to both tests as compared to the control group. After heart transplantation, an increase in vasomotor reactivity was revealed in both vasoconstriction tests. We have found that both plethysmographic techniques provide correlated assessment of changes in the vasomotor response. In addition, we have found that IPG is more resistant to artifacts than APG. The new IPG method has the advantage of measuring blood flow in a contactless manner, making it very promising for experimental evaluation of vasomotor response in clinical conditions.
交感神经血管运动反应是自主循环调节中最重要的部分，它决定了生活质量。在许多疾病中，尤其是在充血性心力衰竭（CHF）患者中，这种反应会受到干扰。然而，由于可用技术有限，反射性血管收缩的实验评估仍然是一项艰巨的任务。本研究的目的是使用新设计的成像体积描记仪（IPG）评估由于心肺压力感受器失活和冷应激导致的前臂血管血管运动反应的动态变化，并将其性能与传统的空气体积描记仪（APG）进行比较。在两种血管收缩测试中，血管运动反应被评估为与静息状态相比，由于静脉阻塞导致的血流速度变化。两项测试均在45名心脏移植前后的CHF患者以及11名年龄匹配的健康志愿者中进行。移植前，与对照组相比，CHF患者在两项测试中均显示出血管运动反应显著降低。心脏移植后，两项血管收缩测试均显示血管运动反应性增加。我们发现两种体积描记技术都能对血管运动反应的变化进行相关评估。此外，我们发现IPG比APG对伪影更具抗性。新的IPG方法具有以非接触方式测量血流的优点，使其在临床条件下对血管运动反应的实验评估非常有前景。
