Sun Der-Shan, Lien Te-Sheng, Chang Hsin-Hou
Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan.
Tzu Chi Med J. 2023 Sep 7;36(1):23-29. doi: 10.4103/tcmj.tcmj_101_23. eCollection 2024 Jan-Mar.
The association between stress and gastrointestinal (GI) tract diseases is well established, while the exact mechanism remains elusive. As a result, it is urgent to establish mouse models to investigate restraint stress-associated GI leakage, but current models have their limitations. A new Evans blue-fed restraint mouse model has recently been developed that allows researchers to study restraint stress-associated GI leakage in live animals. This review article will focus on this model, including its mechanisms, clinical implications, and applications for studying restraint stress-associated GI injury. Recent findings from studies using this model will also be highlighted, along with their potential for diagnosis and treatment. The article aims to discuss about current research and provide recommendations for further study, ultimately improving our understanding of the link between stress and GI injury and improving patient outcomes.
压力与胃肠道疾病之间的关联已得到充分证实，但其确切机制仍不清楚。因此，迫切需要建立小鼠模型来研究束缚应激相关的胃肠道渗漏，但目前的模型存在局限性。最近开发了一种新的喂食伊文思蓝的束缚小鼠模型，使研究人员能够在活体动物中研究束缚应激相关的胃肠道渗漏。这篇综述文章将聚焦于该模型，包括其机制、临床意义以及在研究束缚应激相关胃肠道损伤方面的应用。还将重点介绍使用该模型的研究的最新发现及其在诊断和治疗方面的潜力。本文旨在讨论当前的研究并为进一步研究提供建议，最终增进我们对压力与胃肠道损伤之间联系的理解并改善患者预后。
