School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325001, China.
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
ACS Nano. 2024 Mar 5;18(9):6817-6844. doi: 10.1021/acsnano.3c12072. Epub 2024 Feb 26.
The eye contains a wealth of physiological information and offers a suitable environment for noninvasive monitoring of diseases via smart contact lens sensors. Although extensive research efforts recently have been undertaken to develop smart contact lens sensors, they are still in an early stage of being utilized as an intelligent wearable sensing platform for monitoring various biophysical/chemical conditions. In this review, we provide a general introduction to smart contact lenses that have been developed for disease monitoring and therapy. First, different disease biomarkers available from the ocular environment are summarized, including both physical and chemical biomarkers, followed by the commonly used materials, manufacturing processes, and characteristics of contact lenses. Smart contact lenses for eye-drug delivery with advancing technologies to achieve more efficient treatments are then introduced as well as the latest developments for disease diagnosis. Finally, sensor communication technologies and smart contact lenses for antimicrobial and other emerging bioapplications are also discussed as well as the challenges and prospects of the future development of smart contact lenses.
眼睛包含丰富的生理信息，为通过智能隐形眼镜传感器进行非侵入式疾病监测提供了合适的环境。尽管最近已经进行了广泛的研究工作来开发智能隐形眼镜传感器，但它们作为监测各种生物物理/化学条件的智能可穿戴传感平台仍处于早期阶段。在这篇综述中，我们对用于疾病监测和治疗的智能隐形眼镜进行了一般性介绍。首先，总结了眼内环境中可获得的不同疾病生物标志物，包括物理和化学生物标志物，接着介绍了常用的材料、制造工艺和隐形眼镜的特点。然后介绍了具有先进技术的用于眼部药物输送的智能隐形眼镜，以实现更有效的治疗，以及用于疾病诊断的最新进展。最后，还讨论了传感器通信技术和智能隐形眼镜在抗菌和其他新兴生物应用方面的应用，以及智能隐形眼镜未来发展的挑战和前景。
