Khosravi Arezoo, Zarepour Atefeh, Zarrabi Ali, Iravani Siavash
Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, 34959, Istanbul, Türkiye.
Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, 320315, Taiwan, People's Republic of China.
Nanomicro Lett. 2025 Aug 5;18(1):20. doi: 10.1007/s40820-025-01863-5.
MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology, combining real-time biosensing, therapeutic capabilities, and user comfort in a single platform. These devices take the advantage of the exceptional electrical conductivity, mechanical flexibility, and biocompatibility of two-dimensional MXenes to enable noninvasive, tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels. Recent developments focus on the integration of transparent MXene films into the conventional lens materials, allowing multifunctional performance including photothermal therapy, antimicrobial and anti-inflammation protection, and dehydration resistance. These innovations offer promising strategies for ocular disease management and eye protection. In addition to their multifunctionality, improvements in MXene synthesis and device engineering have enhanced the stability, transparency, and wearability of these lenses. Despite these advances, challenges remain in long-term biostability, scalable production, and integration with wireless communication systems. This review summarizes the current progress, key challenges, and future directions of MXene-based smart contact lenses, highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.
基于MXene的智能隐形眼镜在可穿戴眼科技术方面展现了前沿进展，在单一平台上融合了实时生物传感、治疗能力和用户舒适度。这些设备利用二维MXene卓越的导电性、机械柔韧性和生物相容性，实现对眼内压和葡萄糖水平等关键生理指标的无创、基于泪液的监测。近期的进展集中在将透明MXene薄膜整合到传统镜片材料中，实现包括光热疗法、抗菌和抗炎保护以及抗脱水等多功能性能。这些创新为眼部疾病管理和眼保护提供了有前景的策略。除了多功能性，MXene合成和器件工程方面的改进提高了这些镜片的稳定性、透明度和可佩戴性。尽管取得了这些进展，但在长期生物稳定性、可扩展生产以及与无线通信系统集成方面仍存在挑战。本综述总结了基于MXene的智能隐形眼镜的当前进展、关键挑战和未来方向，突出了它们在下一代数字医疗和眼科护理中的变革潜力。
