Department of Obstetrics and Gynecology, State Key Laboratory of Complex, Severe and Rare Diseases, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730.
Chin Med J (Engl). 2024 Nov 5;137(21):2583-2589. doi: 10.1097/CM9.0000000000002971. Epub 2024 Feb 26.
Uterine fibroids (UFs), the most common tumors in women worldwide, may reduce quality of life and daily activities and even lead to adverse fertility and general health events in patients, causing significant societal health and financial burdens. The objective of this study was to evaluate the global burden through epidemiological trends and examine the potential risk factors for UFs at the national level.
Data on the incidence, prevalence, disability-adjusted life years (DALYs), age-standardized incidence rates (ASIRs), age-standardized prevalence rates (ASPRs), and age-standardized DALY rates for UFs were collected, and the associations with the Human Development Index (HDI) and fertility were evaluated. The age trends in the average annual percent change (AAPC) of the incidence and prevalence rates of UFs were evaluated by joinpoint regression analysis. The associations between lifestyle, metabolic, and socioeconomic factors and the ASIRs of UFs were examined using multivariable linear regression analysis.
The worldwide incidence and prevalence of UFs have been increasing in the past decade, with AAPCs of 0.27% in the incidence rate and 0.078% in the prevalence rate. During 2010-2019, significant increasing trends in UF ASIR were observed in 52 of 88 countries. The age-specific incidence and prevalence of UFs in most age groups showed increasing trends except for 45-54-year-old women which showed no significant trend. Ecological analysis demonstrated no relationship between the incidence of UFs and the HDI but an inverse association with fertility. The incidence of UFs was positively correlated with alcohol intake, hypertension, overweight, and obesity and negatively correlated with smoking.
With the increasing incidence and prevalence worldwide, effective targeted prevention and control of relevant risk factors at the national level should be encouraged to reduce the disease burden of UFs.
子宫肌瘤（UFs）是全球女性最常见的肿瘤，可能会降低生活质量和日常活动能力，甚至导致患者生育能力不良和整体健康状况恶化，给社会带来重大的健康和经济负担。本研究旨在通过流行病学趋势评估全球负担，并在国家层面探讨 UF 的潜在危险因素。
收集 UF 的发病率、患病率、伤残调整生命年（DALYs）、年龄标准化发病率（ASIRs）、年龄标准化患病率（ASPRs）和年龄标准化 DALY 率数据，并评估与人类发展指数（HDI）和生育率的相关性。采用 Joinpoint 回归分析评估 UF 发病率和患病率的年均变化百分比（AAPC）的年龄趋势。采用多元线性回归分析评估生活方式、代谢和社会经济因素与 UF 的 ASIR 之间的关系。
在过去十年中，全球 UF 的发病率和患病率呈上升趋势，发病率的 AAPC 为 0.27%，患病率的 AAPC 为 0.078%。2010-2019 年期间，88 个国家中有 52 个国家的 UF ASIR 呈显著上升趋势。除 45-54 岁女性外，大多数年龄组的 UF 年龄特异性发病率和患病率呈上升趋势，而该年龄组无明显趋势。生态分析表明，UF 的发病率与人类发展指数之间没有关系，但与生育率呈反比关系。UF 的发病率与饮酒、高血压、超重和肥胖呈正相关，与吸烟呈负相关。
由于全球发病率和患病率的增加，应鼓励在国家层面采取有效的有针对性的预防和控制相关危险因素的措施，以减轻 UF 的疾病负担。
