Laboratory of Biology, Control and Surveillance of Vector Insects-LBCVIV FIOCRUZ/RJ, Rio de Janeiro, Brazil.
Laboratory of Medical Entomology, Institute of Scientific and Technological Research of the State of Amapá-IEPA, Macapá, Brazil.
Parasit Vectors. 2024 Feb 26;17(1):88. doi: 10.1186/s13071-023-06064-w.
Aedes aegypti is associated with dengue, Zika, and chikungunya transmission. These arboviruses are responsible for national outbreaks with severe public health implications. Vector control is one of the tools used to prevent mosquito proliferation, and SumiLarv 2MR is an alternative commercial product based on pyriproxyfen for larval/pupal control. In this study, the residual effectiveness of SumiLarv 2MR in different regions of Brazil was evaluated in simulated field conditions.
We conducted a multicenter study across four Brazilian states-Amapá, Pernambuco, Rio de Janeiro, and São Paulo-given the importance to the country's climatic variances in the north, northeast, and southeast regions and their influence on product efficiency. The populations of Ae. aegypti from each location were held in an insectary. Third-instar larvae (L3) were added every 2 weeks to water containers with SumiLarv 2MR discs in 250-, 500- and 1000-l containers in Amapá and Rio de Janeiro, and 100-l containers in Pernambuco and São Paulo, using concentrations of 0.04, 0.08, and 0.16 mg/l.
Adult emergence inhibition over 420 days was observed in all tests conducted at a concentration of 0.16 mg/l; inhibition for 308-420 days was observed for 0.08 mg/l, and 224-420 days for 0.04 mg/l.
Sumilarv 2MR residual activity demonstrated in this study suggests that this new pyriproxyfen formulation is a promising alternative for Aedes control, regardless of climatic variations and ideal concentration, since the SumiLarv 2MR showed adult emergence inhibition of over 80% and residual activity greater than 6 months, a period longer than that recommended by the Ministry of Health of Brazil between product re-application in larval breeding sites.
埃及伊蚊与登革热、寨卡和基孔肯雅热的传播有关。这些虫媒病毒引起了国家爆发，对公共卫生造成了严重影响。病媒控制是预防蚊虫繁殖的工具之一，而 SumiLarv 2MR 是一种基于吡丙醚的新型商业产品，用于幼虫/蛹控制。在这项研究中，评估了 SumiLarv 2MR 在巴西不同地区的模拟现场条件下的残留效果。
我们在巴西的四个州——阿马帕、伯南布哥、里约热内卢和圣保罗——进行了一项多中心研究，考虑到该国北部、东北部和东南部的气候差异及其对产品效率的影响非常重要。来自每个地点的埃及伊蚊种群被饲养在昆虫学实验室中。每隔 2 周，在阿马帕和里约热内卢的 250、500 和 1000 升容器中，以及在伯南布哥和圣保罗的 100 升容器中，用 0.04、0.08 和 0.16mg/L 的浓度加入三龄幼虫（L3）到装有 SumiLarv 2MR 圆盘的水中。
在所有浓度为 0.16mg/L 的测试中，观察到成虫抑制率超过 420 天；在浓度为 0.08mg/L 的测试中，观察到 308-420 天的抑制率，在浓度为 0.04mg/L 的测试中，观察到 224-420 天的抑制率。
本研究中 SumiLarv 2MR 的残留活性表明，这种新的吡丙醚配方是控制埃及伊蚊的一种有前途的替代方法，无论气候变化和理想浓度如何，因为 SumiLarv 2MR 表现出超过 80%的成虫抑制率和超过 6 个月的残留活性，这一时期比巴西卫生部建议的在幼虫繁殖地重新应用产品之间的时间要长。
