Shibuya H, Iwata K, Ohkawa Y, Inui N
Toxicol Lett. 1985 Nov;28(2-3):117-23. doi: 10.1016/0378-4274(85)90019-0.
The combined effects of the xanthine oxidase (XO)-hypoxanthine (HX) system and the various kinds of amino acids in Eagle's minimum essential medium on chromosomal aberrations were studied in Chinese hamster V79 cells. Among 13 amino acids tested, only histidine significantly increased the number of aberrant chromosomes and cytotoxicity in combination with the XO-HX system. This enhancing effect of histidine on chromosomal aberrations was dose-dependent at 0.063% - 0.25%; it was not affected by superoxide dismutase, but was strongly inhibited by catalase.
在中国仓鼠V79细胞中研究了黄嘌呤氧化酶（XO）-次黄嘌呤（HX）系统与伊格尔最低限度基本培养基中各种氨基酸对染色体畸变的联合作用。在所测试的13种氨基酸中，只有组氨酸与XO-HX系统联合使用时能显著增加异常染色体的数量和细胞毒性。组氨酸对染色体畸变的这种增强作用在0.063%-0.25%的浓度范围内呈剂量依赖性；它不受超氧化物歧化酶的影响，但受到过氧化氢酶的强烈抑制。
