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乳腺癌甲状腺转移:病例报告与文献综述

Thyroid Metastases from Breast Cancer Case Report and Literature Review.

作者信息

Guan Yumei, Ma Qinjun, Zhang Yiqing, Zhao Jiuda, Guo Xinjian

机构信息

Breast Disease Diagnosis and Treatment Center, Affiliated Cancer Hospital of Qinghai University, Xining, China.

Pathology Department, Affiliated Cancer Hospital of Qinghai University, Xining, China.

出版信息

Curr Cancer Drug Targets. 2025;25(1):83-95. doi: 10.2174/0115680096274465240129055950.

Abstract

BACKGROUND

Thyroid metastasis arising from primary breast cancer is a rare phenomenon, with only a handful of cases documented in both national and international literature. The management approach and prognosis of this occurrence have sparked debates and uncertainties.

CASE PRESENTATION

Herein, we report the case of a 55-year-old woman with breast cancer. She previously underwent extensive excision of the breast lesion with adjuvant chemotherapy and endocrine therapy. After 9 years, she presented with neck discomfort and examination suggested right thyroid metastasis and lymph node metastasis in the neck. Imaging showed pulmonary and bone metastases. Furthermore, the patient received endocrine therapy. After 7 months of follow- up, the patient survived without any new distant metastases. Thyroid metastases originating from breast cancer often unfold with a subtle, intricate nature, making early detection challenging. They tend to emerge inconspicuously, intertwining with widespread systemic metastases, hinting at a less favorable prognosis.

CONCLUSION

Given the unusual clinical indicators, identifying heterochronic thyroid metastases in patients with tumors poses a distinct challenge, requiring clinicians to navigate the follow-up process with heightened sensitivity. The key lies in timely detection and early intervention, factors that can significantly enhance the overall quality of life for patients.

摘要

背景

原发性乳腺癌引起的甲状腺转移是一种罕见现象,国内外文献中仅有少数病例记载。这种情况的治疗方法和预后引发了争论和不确定性。

病例介绍

在此,我们报告一例55岁乳腺癌女性患者的病例。她之前接受了乳房病变广泛切除术及辅助化疗和内分泌治疗。9年后,她出现颈部不适,检查提示右甲状腺转移及颈部淋巴结转移。影像学检查显示有肺和骨转移。此外,该患者接受了内分泌治疗。经过7个月的随访,患者存活且无任何新的远处转移。源自乳腺癌的甲状腺转移通常呈现出隐匿、复杂的特点,早期检测具有挑战性。它们往往不明显地出现,与广泛的全身转移交织在一起,提示预后较差。

结论

鉴于不寻常的临床指标,识别肿瘤患者的异时性甲状腺转移构成了独特挑战,要求临床医生在随访过程中提高敏感性。关键在于及时检测和早期干预,这些因素可显著提高患者的整体生活质量。

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