Department of Thyroid & Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2021 Mar 12;12:631894. doi: 10.3389/fendo.2021.631894. eCollection 2021.
The thyroid is a rare site for distant metastases from breast carcinoma. The incidence of thyroid metastases in fine needle aspiration biopsy (FNAB) was less than 0.2%.
We report a case of 54-year-old woman with a history of breast carcinoma presented with diffuse scattered microcalcifications in thyroid and enlarged bilateral cervical lymph nodes detected on ultrasound (US). Physical examination of the patient revealed firm and enlarged thyroid lobes.
FNAB and immunohistochemistry (IHC) of the thyroid lesion confirmed the thyroid metastases from breast cancer.
Due to the comorbidities of breast carcinoma metastases to the right axillary, cervical lymph nodes and left chest wall, the patient received chemotherapy. After a follow-up of 19 months, the patient was alive without any new distant metastases.
Our case highlights that thyroid metastases should be considered in a patient combined with thyroid lesions and a history of breast carcinoma. IHC played an important role in differentiating thyroid metastases from primary thyroid cancer.
甲状腺是乳腺癌远处转移的罕见部位。细针穿刺活检（FNAB）中甲状腺转移的发生率小于 0.2%。
我们报告了 1 例 54 岁女性，有乳腺癌病史，超声检查发现甲状腺弥漫性散在微钙化和双侧颈淋巴结肿大。患者体格检查显示甲状腺叶坚实且增大。
甲状腺病变的 FNAB 和免疫组织化学（IHC）证实了乳腺癌甲状腺转移。
由于乳腺癌转移至右侧腋窝、颈部淋巴结和左侧胸壁的合并症，患者接受了化疗。随访 19 个月后，患者存活且无新的远处转移。
我们的病例强调，对于合并甲状腺病变和乳腺癌病史的患者，应考虑甲状腺转移。IHC 在区分甲状腺转移和原发性甲状腺癌方面发挥了重要作用。
