Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, P. R. China.
School of Nursing, Jilin University, Changchun, China.
Food Funct. 2024 Mar 18;15(6):2974-2981. doi: 10.1039/d3fo04614a.
: Dyslipidemia is one of the most common chronic diseases, and is associated with insulin resistance (IR) and inadequate vitamin K intake. We aimed to explore the association between IR, vitamin K intake, and dyslipidemia, and further to explore the mediating role of IR. : 12 860 participants from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018 were included in this study. Insulin resistance was determined by using the homeostatic model assessment for insulin resistance (HOMA-IR). Weighted multiple logistic regression and mediation analyses were conducted to analyze the associations between IR, vitamin K intake, and dyslipidemia. : We found that both vitamin K intake-met Dietary Reference Intake (DRI) and non-IR were protective factors of high triglycerides (with ORs (95% CI) of 0.71 (0.57, 0.87) and 0.36 (0.29, 0.45), respectively) and low high-density lipoprotein cholesterol (with ORs (95% CI) of 0.72 (0.62, 0.82) and 0.39 (0.34, 0.41), respectively). IR-related indicators (HOMA-IR and insulin) partly mediated these effects, and the proportion ranged from 16.36% to 18.52%. : Vitamin K intake-met DRI and non-IR were associated with lower risk of dyslipidemia including high TG and low HDL-C. IR partly mediated the association of vitamin K intake with high TG and low HDL-C.
血脂异常是最常见的慢性疾病之一，与胰岛素抵抗（IR）和维生素 K 摄入不足有关。我们旨在探讨 IR、维生素 K 摄入与血脂异常的关系，并进一步探讨 IR 的中介作用。
本研究纳入了 2001 年至 2018 年国家健康和营养调查（NHANES）的 12860 名参与者。采用稳态模型评估胰岛素抵抗（HOMA-IR）来确定胰岛素抵抗。采用加权多因素 logistic 回归和中介分析来分析 IR、维生素 K 摄入与血脂异常之间的关系。
我们发现，维生素 K 摄入量达到膳食参考摄入量（DRI）和非 IR 都是高甘油三酯（ORs（95%CI）分别为 0.71（0.57，0.87）和 0.36（0.29，0.45））和低高密度脂蛋白胆固醇（ORs（95%CI）分别为 0.72（0.62，0.82）和 0.39（0.34，0.41））的保护因素。IR 相关指标（HOMA-IR 和胰岛素）部分介导了这些作用，其比例范围为 16.36%至 18.52%。
维生素 K 摄入量达到 DRI 和非 IR 与血脂异常（包括高 TG 和低 HDL-C）的风险降低相关。IR 部分介导了维生素 K 摄入与高 TG 和低 HDL-C 之间的关联。
