Zhang Tao, Zhou Ya, Luo Long-Fei, Ji Deng-Jun, Wang Liang, Xie Jun, Zhu An-Ning, Yan Jun-Tao, Yan Zhen, Gong Li, Sun Wu-Quan
Department of Massage, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, China.
Department of Massage, Ningbo Hospital of Traditional Chinese Medicine, Zhejiang University of Traditional Chinese Medicine, China.
J Int Med Res. 2025 Sep;53(9):3000605251367610. doi: 10.1177/03000605251367610. Epub 2025 Sep 4.
ObjectiveSarcopenia poses a significant global public health burden, underscoring the urgency of identifying reliable risk markers for early detection and intervention. This study aimed to elucidate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia as well as explore how various covariates modify this relationship.MethodsA cross-sectional analysis was performed using data from 9040 individuals who participated in the National Health and Nutrition Examination Survey 2011-2018, of whom 721 were diagnosed with sarcopenia. Multivariable logistic regression models were employed to estimate the odds ratios and 95% confidence intervals for the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Restricted cubic spline regression analysis was utilized to assess the nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk. Subgroup analysis was performed to identify the relationship between different subgroups of neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Considering the conflict between the lower age threshold and the diagnostic criteria for sarcopenia, we conducted sensitivity analysis among participants aged ≥40 years.ResultsMultivariable logistic regression analysis revealed that the neutrophil-to-high-density lipoprotein cholesterol ratio was positively associated with sarcopenia risk (odds ratio = 1.16, 95% confidence interval: 1.11-1.22, <0.0001). Restricted cubic spline regression analysis demonstrated a nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (nonlinear <0.05). Subgroup analyses indicated that sex, race, and hyperlipidemia significantly modified the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk ( for interaction <0.05).ConclusionsAn elevated neutrophil-to-high-density lipoprotein cholesterol ratio is associated with a high risk of sarcopenia, indicating that the ratio can effectively assess the risk of sarcopenia and may contribute to early diagnosis and preventive intervention.
目的
肌肉减少症给全球带来了重大的公共卫生负担，凸显了识别可靠风险标志物以进行早期检测和干预的紧迫性。本研究旨在阐明中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症之间的关联，并探讨各种协变量如何改变这种关系。
方法
使用2011 - 2018年参加美国国家健康与营养检查调查的9040名个体的数据进行横断面分析，其中721人被诊断为肌肉减少症。采用多变量逻辑回归模型估计中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症之间关联的比值比和95%置信区间。利用受限立方样条回归分析评估中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症风险之间的非线性关系。进行亚组分析以确定中性粒细胞与高密度脂蛋白胆固醇比值不同亚组与肌肉减少症之间的关系。考虑到较低年龄阈值与肌肉减少症诊断标准之间的冲突，我们在年龄≥40岁的参与者中进行了敏感性分析。
结果
多变量逻辑回归分析显示，中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症风险呈正相关（比值比 = 1.16，95%置信区间：1.11 - 1.22，<0.0001）。受限立方样条回归分析表明中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症风险之间存在非线性关系（非线性<0.05）。亚组分析表明，性别、种族和高脂血症显著改变了中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症风险之间的关联（交互作用<0.05）。
结论
中性粒细胞与高密度脂蛋白胆固醇比值升高与肌肉减少症的高风险相关，表明该比值可有效评估肌肉减少症风险，并可能有助于早期诊断和预防性干预。
