Lu Xuanni, Wang Anqi, Liu Ke, Chen Ying, Chen Weiwei, Mao Yingying, Ye Ding
School of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310053, China.
Biol Trace Elem Res. 2024 Oct 3. doi: 10.1007/s12011-024-04395-y.
We aimed to evaluate the relationship of dietary magnesium intake with all-cause and cause-specific mortality among patients with gout and hyperuricemia (HUA). We analyzed data of 1171 gout patients and 6707 HUA patients from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 and 2001-2018, respectively. Dietary intake data were obtained from 24-h dietary recall interviews. Mortality status was determined using the NHANES public-use linked mortality fill. We used Cox regression model and restricted cubic spline analysis to probe the association of dietary magnesium intake and mortality among gout and HUA patients. During 7081 person-years of follow-up, 257 deaths were documented in gout patients, among which 74 died from cardiovascular disease (CVD) and 48 died from cancer. For HUA patients followed up for 58,216 person-years, 1315 all-cause deaths occurred, including 411 CVD deaths and 224 cancer deaths. After multifactorial adjustments, higher dietary magnesium intake was associated with lower risk of all-cause mortality. Nonlinear negative associations were found between dietary magnesium intake and CVD mortality among gout and HUA patients, with inflection points of 152.5 mg/day and 303 mg/day, respectively, and cancer mortality among HUA patients, with the inflection point of 232 mg/day. The results were robust in subgroup and sensitivity analyses. High dietary magnesium intake is linearly related to all-cause mortality, and nonlinearly associated with cause-specific mortality among gout and HUA patients.
我们旨在评估痛风和高尿酸血症（HUA）患者饮食中镁摄入量与全因死亡率和特定病因死亡率之间的关系。我们分别分析了来自2007 - 2018年国家健康与营养检查调查（NHANES）的1171例痛风患者和2001 - 2018年的6707例HUA患者的数据。饮食摄入数据通过24小时饮食回顾访谈获得。使用NHANES公开可用的关联死亡率文件确定死亡状态。我们使用Cox回归模型和受限立方样条分析来探究痛风和HUA患者饮食中镁摄入量与死亡率之间的关联。在7081人年的随访期间，痛风患者中有257例死亡记录，其中74例死于心血管疾病（CVD），48例死于癌症。对于随访58216人年的HUA患者，发生了1315例全因死亡，包括411例CVD死亡和224例癌症死亡。经过多因素调整后，较高的饮食镁摄入量与较低的全因死亡风险相关。在痛风和HUA患者中，饮食镁摄入量与CVD死亡率之间发现非线性负相关，拐点分别为152.5毫克/天和303毫克/天，在HUA患者中饮食镁摄入量与癌症死亡率之间也呈非线性负相关，拐点为232毫克/天。在亚组分析和敏感性分析中结果稳健。高饮食镁摄入量与全因死亡率呈线性相关，与痛风和HUA患者的特定病因死亡率呈非线性相关。
