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What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension.

作者信息

Kudryashova Tatiana V, Jiang Lifeng, Goncharova Elena A

机构信息

Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Department of Internal Medicine University of California Davis Davis, California.

出版信息

Am J Respir Crit Care Med. 2024 Jun 1;209(11):1298-1300. doi: 10.1164/rccm.202401-0195ED.

DOI:10.1164/rccm.202401-0195ED
PMID:38412504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11146570/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d74/11146570/d31438819a40/rccm.202401-0195EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d74/11146570/d31438819a40/rccm.202401-0195EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d74/11146570/d31438819a40/rccm.202401-0195EDf1.jpg

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本文引用的文献

1
ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.ATP13A3 变异通过破坏多胺转运促进肺动脉高压。
Cardiovasc Res. 2024 May 29;120(7):756-768. doi: 10.1093/cvr/cvae068.
2
Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.Hypusine 信号促进肺动脉高压中的肺血管重塑。
Am J Respir Crit Care Med. 2024 Jun 1;209(11):1376-1391. doi: 10.1164/rccm.202305-0909OC.
3
Pulmonary hypertension.肺动脉高压
Nat Rev Dis Primers. 2024 Jan 4;10(1):1. doi: 10.1038/s41572-023-00486-7.
4
Hypusination-induced DHPS/eIF5A pathway as a new therapeutic strategy for human diseases: A mechanistic review and structural classification of DHPS inhibitors.羟腐胺赖氨酸化诱导的DHPS/eIF5A通路作为人类疾病的一种新治疗策略：DHPS抑制剂的机制综述与结构分类
Biomed Pharmacother. 2023 Nov;167:115440. doi: 10.1016/j.biopha.2023.115440. Epub 2023 Sep 8.
5
Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development.解析肺动脉高压的表观遗传学景观：对个体化医学发展的启示。
J Transl Med. 2023 Jul 17;21(1):477. doi: 10.1186/s12967-023-04339-5.
6
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer.eIF5A 在细胞生命中的多功能作用及其在癌症治疗中的潜力。
Biochem Soc Trans. 2022 Dec 16;50(6):1885-1895. doi: 10.1042/BST20221035.
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Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.亚精胺介导的翻译延伸因子 EIF5A 的高丝氨酸化作用改善线粒体脂肪酸氧化，预防非酒精性脂肪性肝炎进展。
Nat Commun. 2022 Sep 3;13(1):5202. doi: 10.1038/s41467-022-32788-x.
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Front Med (Lausanne). 2022 Jun 28;9:886868. doi: 10.3389/fmed.2022.886868. eCollection 2022.
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Nat Cell Biol. 2022 Mar;24(3):373-383. doi: 10.1038/s41556-022-00848-5. Epub 2022 Feb 17.
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Cell Biosci. 2021 Dec 24;11(1):219. doi: 10.1186/s13578-021-00733-y.