Wang Xiao, Shi Jingwei, Liu Zhengcheng
Department of Thoracic Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Department of Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China.
Mol Clin Oncol. 2024 Feb 9;20(4):28. doi: 10.3892/mco.2024.2726. eCollection 2024 Apr.
Lung cancer is the malignancy with the highest global mortality rate and imposes a substantial burden on society. The increasing popularity of lung cancer screening has led to increasing number of patients being diagnosed with pulmonary nodules due to their potential for malignancy, causing considerable distress in the affected population. However, the diagnosis and treatment of sub-centimeter grade pulmonary nodules remain controversial. The evolution of genetic detection technology and the development of targeted drugs have positioned the diagnosis and treatment of lung cancer in the precision medicine era, leading to a marked improvement in the survival rate of patients with lung cancer. It has been established that lung cancer driver genes serve a key role in the development and progression of sub-centimeter lung cancer. The present review aimed to consolidate the findings on genes associated with sub-centimeter lung cancer, with the intent of serving as a reference for future studies and the personalized management of sub-centimeter lung cancer through genetic testing.
肺癌是全球死亡率最高的恶性肿瘤，给社会带来了沉重负担。肺癌筛查的日益普及导致越来越多的患者因肺部结节具有恶性潜能而被诊断出来，这给受影响人群带来了相当大的困扰。然而，亚厘米级肺部结节的诊断和治疗仍存在争议。基因检测技术的发展和靶向药物的研发使肺癌的诊断和治疗进入了精准医学时代，显著提高了肺癌患者的生存率。已经确定，肺癌驱动基因在亚厘米级肺癌的发生和发展中起关键作用。本综述旨在汇总与亚厘米级肺癌相关基因的研究结果，为未来的研究以及通过基因检测对亚厘米级肺癌进行个性化管理提供参考。
