David L, Leal Ayala H, Tabet J C
J Antibiot (Tokyo). 1985 Dec;38(12):1655-63. doi: 10.7164/antibiotics.38.1655.
A new polyether antibiotic, abierixin, was found in the mycelium of a culture broth of nigericin-producing Streptomyces albus NRRL B-1865. Abierixin was extracted with organic solvents and purified by column chromatography and HPLC. The structure of abierixin was determined by FAB/MS/MS and CI/MS/MS and 1H and 13C NMR spectrometries. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Nigericin biosynthesis from abierixin is discussed.
在产尼日利亚菌素的白色链霉菌NRRL B - 1865培养液的菌丝体中发现了一种新的聚醚抗生素——阿比里新。阿比里新用有机溶剂萃取，并通过柱色谱和高效液相色谱进行纯化。阿比里新的结构通过快原子轰击串联质谱、化学电离串联质谱以及氢核磁共振和碳 - 13核磁共振光谱测定。阿比里新表现出较弱的抗菌和离子载体活性、低毒性但具有良好的抗球虫活性。本文还讨论了由阿比里新合成尼日利亚菌素的过程。
