Department of Public Health Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia.
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia.
Asian Pac J Cancer Prev. 2024 Feb 1;25(2):379-391. doi: 10.31557/APJCP.2024.25.2.379.
Early diagnostic and treatment advances have resulted in prolonged cancer survivorship. Therefore, exercise intervention in survivorship management is essential for enhancing cancer survivors' health-related quality of life (HRQoL).
The systematic review and meta-analysis in this study aimed to explore the effect of exercise intervention on health-related quality of life of colorectal cancer survivors.
The current study followed guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020) to identify relevant literature. Comprehensive searches were conducted using EBSCOhost, Web of Science (WOS), Scopus, Science Direct, and PubMed. The inclusion criteria included are randomised control trials studies written in English, with no restrictions for the time of publication that reported the effects of exercise intervention on health-related quality of live among colorectal cancer survivors. Meta-analysis was conducted by pooling the mean and standard deviation of post-intervention scores across randomised control trial studies using a random effects model.
A total of 467 articles were identified but only seven articles were randomised control trials (RCT) (n = 7) with PEDro scores ranging from 6 to 9 showing good internal validity were included in the review. The results of the meta-analysis of pooled data from six RCTs studies on HRQoL showed no significant effect of exercise intervention on HRQoL in the intervention group compared to control group [SMD = 0.25; 95% CI; -0.0, 0.51; Z = 1.88; p = 0.06; I2 = 30.8%].
This meta-analysis provides key insights into the effect of exercise on the health-related quality of life (HRQoL) of colorectal cancer (CRC) survivors. Therefore, more experimental studies should be carried out with rigorous methodology to evaluate the effectiveness of exercise interventions before it is recommended as a routine activity in post-treatment management for CRC survivors.
早期的诊断和治疗进展导致癌症患者的生存时间延长。因此，在生存管理中进行锻炼干预对于提高癌症患者的健康相关生活质量（HRQoL）至关重要。
本系统综述和荟萃分析旨在探讨锻炼干预对结直肠癌幸存者健康相关生活质量的影响。
本研究遵循 2020 年系统评价和荟萃分析首选报告项目（PRISMA 2020）的指南，以确定相关文献。使用 EBSCOhost、Web of Science（WOS）、Scopus、Science Direct 和 PubMed 进行全面检索。纳入标准包括：英语撰写的随机对照试验研究，无发表时间限制，报告了锻炼干预对结直肠癌幸存者健康相关生活质量的影响。使用随机效应模型，通过汇总随机对照试验研究的后干预评分的均值和标准差对数据进行荟萃分析。
共确定了 467 篇文章，但只有 7 篇随机对照试验（RCT）（n = 7），PEDro 评分从 6 到 9，显示出良好的内部有效性，被纳入综述。荟萃分析结果显示，与对照组相比，锻炼干预对 HRQoL 没有显著影响[SMD = 0.25；95% CI；-0.0，0.51；Z = 1.88；p = 0.06；I2 = 30.8%]。
这项荟萃分析提供了关键的见解，即锻炼对结直肠癌（CRC）幸存者健康相关生活质量（HRQoL）的影响。因此，应该进行更多具有严格方法学的实验研究，以评估锻炼干预的有效性，然后再将其推荐为 CRC 幸存者治疗后管理的常规活动。
