肝癌组织中 PXMP4 的高表达。
High Expression of PXMP4 in Hepatocellular Carcinoma Tissues.
机构信息
Faculty of Medicine, Lincoln University College, Malaysia.
出版信息
Asian Pac J Cancer Prev. 2024 Feb 1;25(2):603-608. doi: 10.31557/APJCP.2024.25.2.603.
OBJECTIVE
To analyze the high expression of peroxisome membrane protein 4 (PXMP4) in hepatocellular carcinoma (HCC) and its clinical significance.
METHODS
The expression of PXMP4 mRNA in HCC tissues and corresponding adjacent tissues was detected by Q-PCR, and the expression of PXMP4 protein was detected by Western blot and immunohistochemistry. The correlation of PXMP4 protein expression with clinicopathological features and prognosis of HCC was analyzed.
RESULTS
The expression levels of PXMP4 mRNA and protein in HCC tissues were significantly higher than those in adjacent tissues (P < 0.05), and its high expression was significantly correlated with tumor differentiation, lymph node metastasis, depth of invasion and TNM stage (P < 0.05). Patients with high expression of PXMP4 had a poor prognosis (P < 0.05).
CONCLUSION
The high expression of PXMP4 may promote the occurrence and development of HCC, and inhibition of PXMP4 may be one of the potential molecular targets for targeted therapy of HCC.
目的
分析过氧化物酶体膜蛋白 4（PXMP4）在肝细胞癌（HCC）中的高表达及其临床意义。
方法
采用 Q-PCR 检测 HCC 组织及相应癌旁组织中 PXMP4mRNA 的表达，采用 Western blot 和免疫组织化学法检测 PXMP4 蛋白的表达，分析 PXMP4 蛋白表达与 HCC 临床病理特征及预后的相关性。
结果
HCC 组织中 PXMP4mRNA 和蛋白的表达水平明显高于癌旁组织（P<0.05），其高表达与肿瘤分化程度、淋巴结转移、浸润深度及 TNM 分期显著相关（P<0.05）。高表达 PXMP4 的患者预后较差（P<0.05）。
结论
PXMP4 的高表达可能促进 HCC 的发生发展，抑制 PXMP4 可能成为 HCC 靶向治疗的潜在分子靶点之一。
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