Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Shandong First Medical University, Jinan, Shandong, China.
Neurochem Res. 2024 Jul;49(7):1628-1642. doi: 10.1007/s11064-024-04118-8. Epub 2024 Feb 28.
Heterotopic ossification (HO) is a pathological process characterized by the aberrant formation of bone in muscles and soft tissues. It is commonly triggered by traumatic brain injury, spinal cord injury, and burns. Despite a wide range of evidence underscoring the significance of neurogenic signals in proper bone remodeling, a clear understanding of HO induced by nerve injury remains rudimentary. Recent studies suggest that injury to the nervous system can activate various signaling pathways, such as TGF-β, leading to neurogenic HO through the release of neurotrophins. These pathophysiological changes lay a robust groundwork for the prevention and treatment of HO. In this review, we collected evidence to elucidate the mechanisms underlying the pathogenesis of HO related to nerve injury, aiming to enhance our understanding of how neurological repair processes can culminate in HO.
异位骨化（HO）是一种病理过程，其特征是肌肉和软组织中出现异常的骨形成。它通常由创伤性脑损伤、脊髓损伤和烧伤引发。尽管有大量证据强调神经信号在适当的骨骼重塑中的重要性，但对于神经损伤引起的 HO 的理解仍然很基础。最近的研究表明，神经系统的损伤可以激活各种信号通路，如 TGF-β，通过神经营养因子的释放导致神经性 HO。这些病理生理变化为 HO 的预防和治疗奠定了坚实的基础。在这篇综述中，我们收集了证据来阐明与神经损伤相关的 HO 发病机制的机制，旨在增强我们对神经修复过程如何导致 HO 的理解。
