Lockerman Larry Z
Clinical Instructor Orofacial Pain, Department of Oral Pathology, Oral Medicine, Maxillofacial Imaging, Tel Aviv University School Dental Medicine, Tel Aviv, Israel.
Evid Based Dent. 2024 Jun;25(2):73-74. doi: 10.1038/s41432-024-00991-y. Epub 2024 Feb 28.
Cooperative analysis of participants and controls.
Wiley Online Library, National Institute of Health, ResearchGate, ScienceDirect, Google Scholar.
Human clinical trials age 18-30 years old, a case-control study included 291 individuals, 192 TMDs and 99 controls. All patients underwent assessment based on a questionnaire and a clinical examination according to Axis I of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Patients who underwent orthodontic treatment were compared to those who did not, regarding their trauma history, bruxism, aggressive teeth brushing, level of oral hygiene, pain scores, muscle tenderness scores and subjective sleep quality.
Medical and/or dental emergencies, subjects with a history of drug, alcohol or medication abuse, fibromyalgia, being pregnant or lactating, having a coexisting mental, psychiatric, or physical disability, cancerous or significant medical problems and the consumption of drugs and/or medications that affect the nervous system including narcotics, TCA (tricyclic antidepressants), anticonvulsant, muscle relaxants and medication overuse headache.
To identify differences between groups, categorical independent variables were analysed using the chi-square test or likelihood ratio, while numeric independent variables were analysed using independent t-tests and analysis of variance (ANOVA). A two-tailed level of statistical significance (α) was established at 0.05. Analysis of multicollinearity was performed following the univariate analyses to examine the collinearity among the independent variables and select independent variables with minimal correlation. Among the highly correlated variables, only one was selected for inclusion in the multivariate model, with the specific variable chosen based on contextual considerations.
The research comprised a total of 291 individuals, consisting of two distinct groups: the TMD group (192 participants, 66%) and the control group (99 participants, 34%). Within the TMD group, further subcategorization was conducted, including MMP (masticatory muscle pain) with 44 individuals (15%); TMJD with 26 individuals (9%); and TMP (both MMP and TMJ) with 122 individuals (42%).
Using a "holistic" and a "collinearity statistical approach and the utilization of a multivariate model" the conclusion is that TMD is not associated with orthodontics.
参与者与对照组的合作分析。
威利在线图书馆、美国国立卫生研究院、ResearchGate、科学Direct、谷歌学术。
年龄在18 - 30岁的人类临床试验，一项病例对照研究纳入了291名个体，其中192例颞下颌关节紊乱症患者和99名对照。所有患者均根据颞下颌关节紊乱症研究诊断标准（RDC/TMD）第一轴的问卷和临床检查进行评估。将接受正畸治疗的患者与未接受正畸治疗的患者在创伤史、磨牙症、用力刷牙、口腔卫生水平、疼痛评分、肌肉压痛评分和主观睡眠质量方面进行比较。
医疗和/或牙科急症、有药物、酒精或药物滥用史的受试者、纤维肌痛、怀孕或哺乳期、并存精神、精神或身体残疾、癌症或重大医疗问题以及使用影响神经系统的药物，包括麻醉剂、三环类抗抑郁药（TCA）、抗惊厥药、肌肉松弛剂和药物过量性头痛。
为了确定组间差异，分类自变量采用卡方检验或似然比分析，数值自变量采用独立t检验和方差分析（ANOVA）。双侧统计显著性水平（α）设定为0.05。在单变量分析之后进行多重共线性分析，以检查自变量之间的共线性并选择相关性最小的自变量。在高度相关的变量中，仅选择一个纳入多变量模型，具体变量根据背景因素选择。
该研究共纳入291名个体，分为两个不同的组：颞下颌关节紊乱症组（192名参与者，66%）和对照组（99名参与者，34%）。在颞下颌关节紊乱症组内，进一步细分，包括咀嚼肌疼痛（MMP）44人（15%）；颞下颌关节紊乱病（TMJD）26人（9%）；以及咀嚼肌疼痛和颞下颌关节紊乱病（TMP，即MMP和TMJ两者）122人（42%）。
采用“整体”和“共线性统计方法”以及多变量模型的运用，得出的结论是颞下颌关节紊乱症与正畸治疗无关。
