牙髓封闭剂引起的遗传毒性：一项系统评价。
Genotoxicity induced by endodontic sealers: A systematic review.
作者信息
Guedes Pinto Thiago, Claudia Muniz Renno Ana, Nunes Dos Santos Jean, Ramos Cury Patricia, Araki Ribeiro Daniel
机构信息
Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
Department of Dental Clinics, Federal University of Bahia, UFBA, Salvador, BA, Brazil.
出版信息
Saudi Dent J. 2024 Feb;36(2):249-257. doi: 10.1016/j.sdentj.2023.11.019. Epub 2023 Nov 17.
INTRODUCTION
This systematic review aimed to help further elucidate the following question: are endodontics sealers able to induce DNA damage in vitro or in vivo?
METHODS
This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement 2020 criteria. A total of 23 studies were carefully selected by the authors.
RESULTS
Regarding the general characteristics, most studies evaluated, on average, 3-5 types of sealers (resin epoxy, salicylate, salicylate + MTA, zinc oxide-eugenol, bioceramic products, calcium hydroxide), performing comparisons between them. Our results demonstrate that endodontic sealers may be a genotoxic agent since most studies demonstrated positive findings, with the resin-based ones being the most potentially genotoxic.
CONCLUSION
The type of genotoxicity assay, material evaluated, and dilution concentration levels influenced the outcome. This study clarifies whether and to what extent endodontic sealers are capable of inducing DNA injury in oral tissues.
引言
本系统评价旨在帮助进一步阐明以下问题：根管封闭剂在体外或体内是否能够诱导DNA损伤？
方法
本研究按照2020年系统评价和Meta分析的首选报告项目（PRISMA）声明标准进行。作者共精心挑选了23项研究。
结果
关于一般特征，大多数研究平均评估3 - 5种类型的封闭剂（树脂环氧树脂、水杨酸盐、水杨酸盐+MTA、氧化锌丁香酚、生物陶瓷产品、氢氧化钙），并对它们进行比较。我们的结果表明，根管封闭剂可能是一种基因毒性剂，因为大多数研究显示出阳性结果，其中树脂基封闭剂潜在基因毒性最大。
结论
基因毒性测定类型、评估材料和稀释浓度水平影响了结果。本研究阐明了根管封闭剂是否以及在何种程度上能够诱导口腔组织中的DNA损伤。
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