Arumugam Sankar, Suyambulingam Anbalagan
General Medicine, Sree Balaji Medical College and Hospital, Chennai, IND.
Cureus. 2024 Jan 28;16(1):e53117. doi: 10.7759/cureus.53117. eCollection 2024 Jan.
Hyperinsulinemia has been linked to increased ferritin production and iron absorption in type 2 diabetes mellitus, ultimately leading to increased iron storage. Glucose intolerance is intimately linked to this issue. Increased oxidative stress from iron decreases insulin's ability to be taken into cells and used for energy. Researchers suggest that increased iron levels in the body play a role in the emergence of insulin resistance, glucose intolerance, and vascular repercussions associated with diabetes.
The aim of this study is to assess the levels of serum ferritin and fasting plasma glucose in both diabetic and nondiabetic individuals while establishing a relationship between the two. Exploring the connection between serum ferritin levels and the duration of diabetes mellitus in individuals diagnosed with diabetes is our objective.
In this study, 80 men diagnosed with type 2 diabetes mellitus were included, and they were compared with 70 male volunteers who were in good health. We took blood samples while the subjects fasted, and we analyzed the plasma glucose and serum ferritin levels.
In the diabetic group, there were notably higher levels of serum ferritin and fasting plasma glucose compared to the nondiabetic subjects. Furthermore, a correlation was observed between the duration of diabetes among participants with diabetes and elevated serum ferritin levels.
The findings suggest that low-grade inflammation and increased body iron stores are positively related to hyperglycemia in type 2 diabetes mellitus.
高胰岛素血症与2型糖尿病中铁蛋白生成增加和铁吸收增加有关，最终导致铁储存增加。葡萄糖耐量异常与这个问题密切相关。铁产生的氧化应激增加会降低胰岛素进入细胞并用于能量的能力。研究人员认为，体内铁水平升高在与糖尿病相关的胰岛素抵抗、葡萄糖耐量异常和血管病变的出现中起作用。
本研究的目的是评估糖尿病患者和非糖尿病患者的血清铁蛋白水平和空腹血糖水平，同时建立两者之间的关系。我们的目标是探索血清铁蛋白水平与糖尿病患者糖尿病病程之间的联系。
本研究纳入了80名被诊断为2型糖尿病的男性，并将他们与70名健康男性志愿者进行比较。在受试者空腹时采集血样，并分析血浆葡萄糖和血清铁蛋白水平。
与非糖尿病受试者相比，糖尿病组的血清铁蛋白水平和空腹血糖水平明显更高。此外，观察到糖尿病患者的糖尿病病程与血清铁蛋白水平升高之间存在相关性。
研究结果表明，低度炎症和体内铁储存增加与2型糖尿病中的高血糖呈正相关。
