血清铁蛋白：过去、现在与未来。
Serum ferritin: Past, present and future.
作者信息
Wang Wei, Knovich Mary Ann, Coffman Lan G, Torti Frank M, Torti Suzy V
机构信息
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
出版信息
Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. Epub 2010 Mar 19.
Abstract
BACKGROUND
Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases.
SCOPE OF REVIEW
In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool.
MAJOR CONCLUSIONS
Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer.
GENERAL SIGNIFICANCE
Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.
摘要
背景
血清铁蛋白于20世纪30年代被发现，并于20世纪70年代发展成为一项临床检测项目。许多疾病都与铁过载或铁缺乏有关。血清铁蛋白被广泛用于这些疾病的诊断和监测。
综述范围
在本章中，我们讨论血清铁蛋白在生理和病理过程中的作用及其作为临床工具的用途。
主要结论
尽管血清铁蛋白基础生物学的许多方面仍令人惊讶地不清楚，但细胞外铁蛋白的作用越来越多，包括在铁运输、血管生成、炎症、免疫、信号传导和癌症方面新描述的作用。
普遍意义
血清铁蛋白仍然是一种临床有用的工具。对这种蛋白质生物学的进一步研究可能会提供新的生物学见解。
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