Venugopala Katharigatta N, Kamat Vinuta
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban 4001, South Africa.
Pharmaceuticals (Basel). 2024 Sep 24;17(10):1258. doi: 10.3390/ph17101258.
Pyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not many technical skills are needed. All these factors attract chemists to focus more on pyrimidines. Apart from the synthesis of biological applications of pyrimidines, medicinal chemists have gathered to explore more pyrimidine scaffolds due to their interesting medicinal properties and easy targeting of various binding sites. This review delves into the diverse biological activities of compounds derived from pyrimidine during the year 2024. We have attempted to explore the growing significance of pyrimidine derivatives and provide a new path for designing new potent molecules.
嘧啶是一种存在于生物体内的基团，在药理学中具有多种重要的生物学特性。由于合成操作简便、前体易于获得且反应时间较短，该合成过程不需要太多技术技能。所有这些因素吸引化学家更多地关注嘧啶。除了嘧啶在生物学应用方面的合成，药物化学家们还聚集在一起探索更多嘧啶骨架，因为它们具有有趣的药用特性且易于靶向各种结合位点。本综述深入探讨了2024年源自嘧啶的化合物的多样生物活性。我们试图探索嘧啶衍生物日益增长的重要性，并为设计新的强效分子提供一条新途径。
