酿酒酵母中的线粒体诱变。II. 甲磺酸甲酯和1,4 - 丁二醇二缩水甘油醚
Mitochondrial mutagenesis in Saccharomyces cerevisiae. II. Methyl methanesulphonate and diepoxybutane.
作者信息
Polakowska R, Putrament A
出版信息
Mutat Res. 1979 Jul;61(2):207-13. doi: 10.1016/0027-5107(79)90127-1.
PMID:384223
Abstract
In Saccharomyces cerevisiae, methyl methanesulphonate and diepoxybutane produced efficiently lethal, as well as mutagenic, damage in nuclear DNA. However, in the same conditions, these agents did not induce cytoplasmic petite mutations and poorly induced point mutations (resistance to erythromycin and chloramphenicol) in mitochondrial DNA. Possible reasons for these differences are discussed.
摘要
在酿酒酵母中，甲磺酸甲酯和1,4 - 二环氧丁烷能有效产生致死性以及诱变性的核DNA损伤。然而，在相同条件下，这些试剂不会诱导线粒体DNA产生细胞质小菌落突变，且诱导线粒体DNA点突变（对红霉素和氯霉素的抗性）的能力较弱。文中讨论了造成这些差异的可能原因。
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