Diaz-Castro Javier, Reyes-Olavarría Daniela, Toledano Juan M, Puche-Juarez María, Garcia-Vega Jose Eulogio, Ochoa Julio J, Moreno-Fernandez Jorge
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain; Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, 18071 Granada, Spain; Instituto de Investigación Biosanitaria (IBS), 18016 Granada, Spain.
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain; Institute of Nutrition and Food Technology "José Mataix Verdú", University of Granada, 18071 Granada, Spain; Nutrition and Food Sciences Ph.D. Program, University of Granada, 18071 Granada, Spain; Department of Physical Education, Sport, and Recreation, Universidad de La Frontera, Temuco 4780000, Chile.
Clin Nutr. 2024 Apr;43(4):936-942. doi: 10.1016/j.clnu.2024.02.024. Epub 2024 Feb 26.
BACKGROUND & AIMS: Regular and planned physical activity can diminish the risk of numerous illnesses. However, school children and teenagers often exercise intermittently and for brief periods, restricting potential benefits. Furthermore, previous studies mainly focused on body composition, without providing molecular mechanisms elucidating the role of physical activity in muscle tissue and inflammatory signalling. The objective of this study was to determine the effect of a vigorous physical activity intervention on endocrine muscle function and cytokine output in children.
103 boys were divided into two groups: control (n = 51, did not perform additional physical activity) and exercise (n = 52, performed vigorous physical activity). Body composition measurements, endocrine muscle function and inflammatory signalling biomarkers were assessed at enrolment and after 6 months of intervention.
No statistical significance was found for fractalkine, oncostatin, EGF, TNF-α and eotaxin. However, LIF, FBAP3, IL-6, FGF21 and IL-15 increased in the exercise group at the end of the protocol, though myostatin got decreased. In contrast, IFN-γ was increased in the exercise group at the beginning and end of the exercise protocol, IL-10 was also increased in this group, IL-1α decreased in the exercise group before and after the exercise protocol, and IP-10 and MCP-1 also decreased in the exercise group.
It can be affirmed that a physical activity programme for boys was shown to produce changes in body composition (decreased fat mass, increased lean mass) and in markers of endocrine muscle function and cytokine release. It is possible that these changes, if sustained, could reduce the risk of chronic disease.
规律且有计划的体育活动可降低多种疾病的风险。然而，学童和青少年经常进行间歇性且短暂的锻炼，限制了潜在益处。此外，以往研究主要聚焦于身体成分，未阐明体育活动在肌肉组织和炎症信号传导中的分子机制。本研究的目的是确定剧烈体育活动干预对儿童内分泌肌肉功能和细胞因子输出的影响。
103名男孩被分为两组：对照组（n = 51，未进行额外体育活动）和运动组（n = 52，进行剧烈体育活动）。在入组时和干预6个月后评估身体成分测量、内分泌肌肉功能和炎症信号生物标志物。
趋化因子、制瘤素、表皮生长因子、肿瘤坏死因子-α和嗜酸性粒细胞趋化因子未发现统计学意义。然而，在方案结束时，运动组的白血病抑制因子、FBAP3、白细胞介素-6、成纤维细胞生长因子21和白细胞介素-15增加，而肌肉生长抑制素减少。相比之下，运动组在运动方案开始和结束时干扰素-γ增加，该组白细胞介素-10也增加，运动组在运动方案前后白细胞介素-1α减少，运动组的IP-10和单核细胞趋化蛋白-1也减少。
可以肯定的是，一项针对男孩的体育活动计划显示出身体成分（脂肪量减少、瘦体重增加）以及内分泌肌肉功能和细胞因子释放标志物的变化。如果这些变化持续下去，有可能降低慢性病风险。
