POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizábal, 3, 20018 Donostia-San Sebastián, Spain.
POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizábal, 3, 20018 Donostia-San Sebastián, Spain; Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), CONICET, Güemes 3450, Santa Fe 3000, Argentina.
Adv Drug Deliv Rev. 2024 Apr;207:115217. doi: 10.1016/j.addr.2024.115217. Epub 2024 Feb 27.
The development of innovative products for treating acute and chronic wounds has become a significant topic in healthcare, resulting in numerous products and innovations over time. The growing number of patients with comorbidities and chronic diseases, which may significantly alter, delay, or inhibit normal wound healing, has introduced considerable new challenges into the wound management scenario. Researchers in academia have quickly identified promising solutions, and many advanced wound healing materials have recently been designed; however, their successful translation to the market remains highly complex and unlikely without the contribution of industry experts. This review article condenses the main aspects of wound healing applications that will serve as a practical guide for researchers working in academia and industry devoted to designing, evaluating, validating, and translating polymer wound care materials to the market. The article highlights the current challenges in wound management, describes the state-of-the-art products already on the market and trending polymer materials, describes the regulation pathways for approval, discusses current wound healing models, and offers a perspective on new technologies that could soon reach consumers. We envision that this comprehensive review will significantly contribute to highlighting the importance of networking and exchanges between academia and healthcare companies. Only through the joint of these two actors, where innovation, manufacturing, regulatory insights, and financial resources act in harmony, can wound care products be developed efficiently to reach patients quickly and affordably.
治疗急性和慢性伤口的创新产品的开发已成为医疗保健领域的一个重要课题,随着时间的推移,出现了许多产品和创新。患有合并症和慢性病的患者数量不断增加,这些疾病可能会显著改变、延迟或抑制正常的伤口愈合,这给伤口管理带来了相当大的新挑战。学术界的研究人员迅速确定了有希望的解决方案,并且最近设计了许多先进的伤口愈合材料;然而,如果没有行业专家的贡献,它们成功推向市场仍然非常复杂且不太可能。本文综述了伤口愈合应用的主要方面,为致力于设计、评估、验证和将聚合物伤口护理材料推向市场的学术界和工业界的研究人员提供了实用指南。文章重点介绍了伤口管理中的当前挑战,描述了已经上市和流行的聚合物材料的最新产品,描述了批准的监管途径,讨论了当前的伤口愈合模型,并对不久将推向消费者的新技术进行了展望。我们设想,这篇全面的综述将极大地有助于强调学术界和医疗保健公司之间建立联系和交流的重要性。只有通过这两个参与者的合作,创新、制造、监管洞察力和财务资源协调一致,才能高效地开发伤口护理产品,以便快速、经济实惠地为患者提供服务。