Winkler Nicole, Peterson Michael, Factor Rachel
University of Utah Health/Huntsman Cancer Institute, Department of Radiology and Imaging Sciences, Salt Lake City, UT, USA.
University of Utah School of Medicine, Department of Radiology and Imaging Sciences, Salt Lake City, UT, USA.
J Breast Imaging. 2021 Sep 16;3(5):597-602. doi: 10.1093/jbi/wbab051.
Fibromatosis of the breast is a rare, benign locally infiltrative tumor without metastatic potential. Patients typically present with a painless, palpable, firm breast mass, which may be mobile or fixed to the pectoralis muscle. While some cases are related to familial mutations in the adenomatous polyposis coli (APC) gene, the majority are sporadic due to somatic mutations or prior injury to the breast tissue. On mammography, fibromatosis is typically seen as an irregular, dense, spiculated mass. US demonstrates a hypoechoic, irregular mass with indistinct margins. Fibromatosis is indistinguishable from breast cancer on imaging, and core biopsy is required for definitive diagnosis. Wide local excision is the historical standard for treatment; however, recurrence rates are high, and other emerging therapies are being explored. This article reviews the clinical features, imaging and histopathologic findings, along with brief overview of management.
乳腺纤维瘤病是一种罕见的、良性的、具有局部浸润性且无转移潜能的肿瘤。患者通常表现为可触及的无痛性、质地硬的乳腺肿块，该肿块可能可活动或与胸大肌固定。虽然一些病例与腺瘤性息肉病 coli（APC）基因的家族性突变有关，但大多数是由于体细胞突变或乳腺组织先前损伤导致的散发性病例。在乳腺钼靶检查中，纤维瘤病通常表现为不规则、致密、有毛刺的肿块。超声显示为低回声、不规则肿块，边界不清。在影像学上，纤维瘤病与乳腺癌难以区分，需要进行核心活检以明确诊断。广泛局部切除是过去的治疗标准；然而，复发率很高，目前正在探索其他新兴疗法。本文综述了其临床特征、影像学和组织病理学表现，并简要概述了治疗方法。
