School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4215, Australia.
Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi Arabia.
Drug Discov Today. 2024 Apr;29(4):103936. doi: 10.1016/j.drudis.2024.103936. Epub 2024 Feb 29.
This review highlights the transformative impact of microfluidic technology on personalized drug delivery. Microfluidics addresses issues in traditional drug synthesis, providing precise control and scalability in nanoparticle fabrication, and microfluidic platforms show high potential for versatility, offering patient-specific dosing and real-time monitoring capabilities, all integrated into wearable technology. Covalent conjugation of antibodies to nanoparticles improves bioactivity, driving innovations in drug targeting. The integration of microfluidics with sensor technologies and artificial intelligence facilitates real-time feedback and autonomous adaptation in drug delivery systems. Key challenges, such as droplet polydispersity and fluidic handling, along with future directions focusing on scalability and reliability, are essential considerations in advancing microfluidics for personalized drug delivery.
这篇综述强调了微流控技术对个性化药物输送的变革性影响。微流控技术解决了传统药物合成中的问题，在纳米颗粒制造中提供了精确的控制和可扩展性，并且微流控平台在多功能性方面显示出巨大的潜力，能够提供患者特异性剂量和实时监测能力，所有这些都集成到可穿戴技术中。抗体与纳米颗粒的共价偶联提高了生物活性，推动了药物靶向的创新。微流控技术与传感器技术和人工智能的集成促进了药物输送系统的实时反馈和自主适应。关键挑战，如液滴多分散性和流体处理，以及未来关注可扩展性和可靠性的方向，都是推进个性化药物输送用微流控技术的重要考虑因素。
