LPL 基因 rs301 变异的成年咖啡饮用者的代谢综合征风险。

Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene.

机构信息

Department of Obstetrics and Gynecology, Chung-Kang Branch, Cheng Ching Hospital, Taichung City, 407, Taiwan.

Department of Public Health, Institute of Public Health, Chung Shan Medical University, Taichung, 40201, Taiwan.

出版信息

Nutr J. 2024 Mar 2;23(1):30. doi: 10.1186/s12937-024-00931-7.

DOI:10.1186/s12937-024-00931-7

PMID:38429792

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10908173/

Abstract

BACKGROUND

Metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors is influenced by environmental, lifestyle, and genetic factors. We explored whether coffee consumption and the rs301 variant of the lipoprotein lipase (LPL) gene are related to MetS.

METHODS

We conducted multiple logistic regression analyses using data gathered from 9523 subjects in Taiwan Biobank (TWB).

RESULTS

Our findings indicated that individuals who consumed coffee had a reduced odds ratio (OR) for MetS (0.750 (95% confidence interval [CI] 0.653-0.861) compared to non-coffee drinkers. Additionally, the risk of MetS was lower for individuals with the 'TC' and 'CC' genotypes of rs301 compared to those with the 'TT' genotype. Specifically, the OR for MetS was 0.827 (95% CI 0.721-0.949) for the 'TC' genotype and 0.848 (95% CI 0.610-1.177) for the 'CC' genotype. We observed an interaction between coffee consumption and the rs301 variant, with a p-value for the interaction of 0.0437. Compared to the reference group ('no coffee drinking/TT'), the ORs for MetS were 0.836 (95% CI 0.706-0.992) for 'coffee drinking/TT', 0.557 (95% CI 0.438-0.707) for 'coffee drinking/TC', and 0.544 (95% CI 0.319-0.927) for 'coffee drinking/CC'. Notably, MetS was not observed in non-coffee drinkers regardless of their rs301 genotype.

CONCLUSION

Our findings suggest that rs301 genotypes may protect against MetS in Taiwanese adults who consume coffee compared to non-coffee drinkers.

摘要

背景

代谢综合征（MetS）是一组代谢和心血管危险因素，受环境、生活方式和遗传因素的影响。我们探讨了咖啡消费和脂蛋白脂肪酶（LPL）基因的 rs301 变体是否与 MetS 有关。

方法

我们使用来自台湾生物银行（TWB）的 9523 名受试者的数据进行了多项逻辑回归分析。

结果

我们的研究结果表明，与不喝咖啡的人相比，喝咖啡的人患 MetS 的几率较低（0.750（95%置信区间[CI]0.653-0.861）。此外，与 rs301 的 TT 基因型相比，TC 和 CC 基因型的个体患 MetS 的风险较低。具体来说，TC 基因型的 MetS 比值比为 0.827（95%CI0.721-0.949），CC 基因型的 MetS 比值比为 0.848（95%CI0.610-1.177）。我们观察到咖啡消费和 rs301 变体之间存在交互作用，交互作用的 p 值为 0.0437。与参考组（“不喝咖啡/TT”）相比，MetS 的比值比为 0.836（95%CI0.706-0.992），“喝咖啡/TT”，0.557（95%CI0.438-0.707）用于“喝咖啡/TC”，0.544（95%CI0.319-0.927）用于“喝咖啡/CC”。值得注意的是，无论 rs301 基因型如何，不喝咖啡的人都没有观察到 MetS。