Department of Chemistry, School of Natural Sciences Institution, Shiv Nadar Institution of Eminence (SNIoE), Delhi NCR, Greater Noida, Uttar Pradesh, 201314, India.
Chem Asian J. 2024 Apr 16;19(8):e202400056. doi: 10.1002/asia.202400056. Epub 2024 Mar 27.
Ferroptosis is a recently identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Numerous functions for ferroptosis have been identified in physiological as well as pathological processes, most notably in the treatment of cancer. The intricate balance of redox homeostasis is profoundly altered during ferroptosis, leading to alteration in cellular microenvironment. One such microenvironment is viscosity among others such as pH, polarity, and temperature. Therefore, understanding the dynamics of ferroptosis associated viscosity levels within organelles is crucial. To date, there are a very few reviews that detects ferroptosis assessing reactive species. In this review, we have summarized organelle's specific fluorescent probes that detects dynamics of microviscosity during ferroptosis. Also, we offer the readers an insight of their design strategy, photophysics and associated bioimaging concluding with the future perspective and challenges in the related field.
铁死亡是一种新近发现的细胞程序性死亡方式，其特征为铁蓄积和脂质过氧化。在生理和病理过程中，铁死亡已经被发现具有多种功能，尤其是在癌症治疗方面。在铁死亡过程中，氧化还原平衡的精细平衡被严重改变，导致细胞微环境的改变。细胞微环境的一个例子是粘度，其他例子还有 pH 值、极性和温度等。因此，了解细胞器中与铁死亡相关的粘度水平的动力学变化至关重要。迄今为止，只有少数几篇综述检测到铁死亡时的活性物质。在这篇综述中，我们总结了细胞器特异性荧光探针，用于检测铁死亡过程中的微粘度动力学。此外，我们还为读者提供了它们的设计策略、光物理特性以及相关生物成像的深入了解，最后对相关领域的未来展望和挑战进行了总结。
