小分子荧光探针在研究铁死亡中的最新进展。
Recent advances in small-molecule fluorescent probes for studying ferroptosis.
机构信息
Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China.
Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou 450018, China.
出版信息
Chem Soc Rev. 2022 Sep 20;51(18):7752-7778. doi: 10.1039/d1cs01167g.
Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death driven by excessive lipid peroxidation (LPO). Mounting evidence suggests that the unique modality of cell death is involved in the development and progression of several diseases including cancer, cardiovascular diseases (CVDs), neurodegenerative disorders, However, the pathogenesis and signalling pathways of ferroptosis are not fully understood, possibly due to the lack of robust tools for the highly selective and sensitive imaging of ferroptosis analytes in complex living systems. Up to now, various small-molecule fluorescent probes have been applied as promising chemosensors for studying ferroptosis through tracking the biomolecules or microenvironment-related parameters and . In this review, we comprehensively reviewed the recent development of small-molecule fluorescent probes for studying ferroptosis, with a focus on the analytes, design strategies and bioimaging applications. We also provided new insights to overcome the major challenges in this emerging field.
铁死亡是一种由脂质过氧化（LPO）过度驱动的铁依赖性、非细胞凋亡的程序性细胞死亡形式。越来越多的证据表明，这种独特的细胞死亡方式与包括癌症、心血管疾病（CVDs）、神经退行性疾病在内的几种疾病的发生和发展有关。然而，铁死亡的发病机制和信号通路尚未完全阐明，这可能是由于缺乏在复杂的活体系统中对铁死亡分析物进行高选择性和高灵敏度成像的稳健工具所致。到目前为止，各种小分子荧光探针已被用作研究铁死亡的有前途的化学传感器，通过跟踪生物分子或与微环境相关的参数。在这篇综述中，我们全面回顾了用于研究铁死亡的小分子荧光探针的最新进展，重点介绍了分析物、设计策略和生物成像应用。我们还为克服这一新兴领域的主要挑战提供了新的见解。
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