Department of Basic and Clinical Sciences, University of Nicosia Medical School, 21 Ilia Papakyriakou, 2414 Engomi P.O. Box 24005, CY-1700, Nicosia, Cyprus.
Curr Nutr Rep. 2024 Jun;13(2):113-125. doi: 10.1007/s13668-024-00522-2. Epub 2024 Mar 2.
Acute Myeloid Leukaemia (AML) constitutes a mere 1% of global cancer cases. This scoping review aims to investigate the association between nutrition and the development of AML, providing a foundation for future research in this field.
A systematic search was conducted across PubMed, EBSCO, Taylor and Francis, Science Direct and Cochrane Library using specific keywords. Inclusion criteria comprised observational studies and clinical trials examining the association between nutrition and the development of AML. Articles selected for analysis were restricted to those published in English between 1990-2023, and available as full text articles. Among the twenty-five articles that were screened, only six met the criteria for data extraction. Four studies did not reveal statistically significant correlations between nutrition and the development of AML, while two studies provided evidence for significant associations. The findings indicated increased AML risk associated with (a) heightened caloric intake, consumption of white potatoes, and red meat (pork and beef) and (b) diminished consumption of vegetables, seafood, nuts, and seeds. The scarcity of comprehensive studies exploring the connection between nutrition and AML, highlights the urgent need for additional research, encompassing pre-clinical studies. This imperative is critical for enhancing our understanding of the molecular mechanisms that underlie the connection between diet and the aetiology of AML. Such knowledge is paramount in advancing effective strategies for both prevention and management of this significant disease.
急性髓细胞白血病（AML）仅占全球癌症病例的 1%。本范围综述旨在调查营养与 AML 发展之间的关联，为该领域的未来研究奠定基础。
使用特定关键字在 PubMed、EBSCO、Taylor 和 Francis、Science Direct 和 Cochrane Library 中进行了系统搜索。纳入标准包括观察性研究和临床试验，研究营养与 AML 发展之间的关联。选择进行分析的文章仅限于 1990 年至 2023 年期间以英文发表的、可作为全文文章的文章。在筛选的二十五篇文章中，只有六篇符合提取数据的标准。四项研究没有显示营养与 AML 发展之间存在统计学上的显著相关性，而两项研究提供了显著关联的证据。研究结果表明，（a）热量摄入增加、白土豆和红肉（猪肉和牛肉）的摄入以及（b）蔬菜、海鲜、坚果和种子的摄入减少与 AML 风险增加有关。缺乏全面研究探索营养与 AML 之间的联系，突显了迫切需要进行更多的研究，包括临床前研究。这对于增强我们对饮食与 AML 发病机制之间联系的分子机制的理解至关重要。这种知识对于推进预防和管理这种重大疾病的有效策略至关重要。
