World Bank Africa Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port-Harcourt, Rivers State, Nigeria.
School of Natural and Applied Sciences, Kampala International University, Kampala, Uganda.
Curr Top Med Chem. 2021;21(12):1067-1095. doi: 10.2174/1568026621666210509161059.
Type 2 diabetes (adult onset diabetes) is the most common type of diabetes, accounting for around 90% of all diabetes cases with insulin resistance and insulin secretion defect. The key goal of anti-diabetic therapy is to increase the development of insulin, immunity and/or decrease the amount of blood glucose. While many synthetic compounds have been produced as antidiabetic agents, due to their side effects and limited effectiveness, their usefulness has been hindered.
This systematic review investigated the bioactive compounds reported to possess activities against type 2 diabetes. Three (3) databases, PubMed, ScienceDirect and Google Scholar were searched for research articles published between January 2010 and October 2020. A total of 6464 articles were identified out of which 84 articles were identified to be elligible for the study.
From the data extracted, it was found that quercetin, Kaempferol, Rosmarinic acid, Cyanidin, Rutin, Catechin, Luteolin and Ellagic acid were the most cited bioactive compounds which all falls within the class of polyphenolic compounds. The major sources of these bioactive compounds includes citrus fruits, grapes, onions, berries, cherries, broccoli, honey, apples, green tea, Ginkgo biloba, St. John's wort, green beans, cucumber, spinach, tea, Rosmarinus officinalis, Aloe vera, Moringa oleifera, tomatoes, potatoes, oregano, lemon balm, thyme, peppermint, Ocimum basilicum, red cabbage, pears, olive oil and walnut.
2 型糖尿病（成人发病型糖尿病）是最常见的糖尿病类型，约占所有糖尿病病例的 90%，其特征为胰岛素抵抗和胰岛素分泌缺陷。抗糖尿病治疗的关键目标是增加胰岛素的产生、免疫和/或减少血糖量。虽然已经生产了许多合成化合物作为抗糖尿病剂，但由于其副作用和有限的有效性，其用途受到了阻碍。
本系统评价研究了报道具有 2 型糖尿病活性的生物活性化合物。在 PubMed、ScienceDirect 和 Google Scholar 这三个数据库中，检索了 2010 年 1 月至 2020 年 10 月期间发表的研究文章。从已确定的 6464 篇文章中，确定了 84 篇符合研究条件的文章。
从提取的数据中发现，槲皮素、山奈酚、迷迭香酸、矢车菊素、芦丁、儿茶素、木犀草素和鞣花酸是被引用最多的生物活性化合物，它们都属于多酚类化合物。这些生物活性化合物的主要来源包括柑橘类水果、葡萄、洋葱、浆果、樱桃、西兰花、蜂蜜、苹果、绿茶、银杏、贯叶金丝桃、绿豆、黄瓜、菠菜、茶、迷迭香、芦荟、辣木、西红柿、土豆、牛至、柠檬香脂、百里香、薄荷、罗勒、紫甘蓝、梨、橄榄油和核桃。
