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[用支原体脂多糖体外刺激白细胞产生促凝血活性]

[Generation of pro-coagulation activity by leukocytes stimulated in vitro with lipoglycans from mycoplasmas].

作者信息

Monno R A, Barone G, Fumarola D, Miragliotta G

出版信息

G Batteriol Virol Immunol. 1985 Jul-Dec;78(7-12):144-54.

PMID:3843073
Abstract

Lipoglycans represent a special type of lipopoly-saccharide that differs in structure from the well-known gram-negative bacteria lipopolysaccharide. After briefly describing their most important characteristics, the authors take into consideration the in vitro interaction between lipoglycans from Acholeplasma granularum, Acholeplasma oculi, and Acholeplasma axanthum and human leukocytes in terms of production of procoagulant activity. The results obtained show that the examined lipoglycans possess, similarly to lipopolysaccharides, the capacity to induce the production of procoagulant activity, thromboplastin-like, from human mononuclear cells. However, the pathophysiological significance of this endotoxin-like activity remains to be established.

摘要

脂聚糖是一种特殊类型的脂多糖,其结构与著名的革兰氏阴性菌脂多糖不同。在简要描述了它们最重要的特征之后,作者考虑了颗粒无胆甾原体、眼无胆甾原体和黄无胆甾原体的脂聚糖与人类白细胞之间的体外相互作用,涉及促凝血活性的产生。所得结果表明,所检测的脂聚糖与脂多糖类似,具有诱导人类单核细胞产生促凝血活性(类凝血活酶)的能力。然而,这种内毒素样活性的病理生理学意义仍有待确定。

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1
[Generation of pro-coagulation activity by leukocytes stimulated in vitro with lipoglycans from mycoplasmas].[用支原体脂多糖体外刺激白细胞产生促凝血活性]
G Batteriol Virol Immunol. 1985 Jul-Dec;78(7-12):144-54.
2
Induction of procoagulant activity in human leukocytes with lipoglycans from mycoplasmas.支原体脂多糖诱导人白细胞促凝血活性
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Endotoxin-like activities of mycoplasmal lipopolysaccharides (lipoglycans).支原体脂多糖(脂聚糖)的类内毒素活性
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Identification of the major antigenic determinants on lipoglycans from Acholeplasma granularum and Acholeplasma axanthum.颗粒无胆甾原体和黄色无胆甾原体脂聚糖上主要抗原决定簇的鉴定。
Infect Immun. 1983 May;40(2):629-32. doi: 10.1128/iai.40.2.629-632.1983.
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Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles.脂多糖刺激产生的单核细胞白细胞介素-10通过抑制组织因子表达和活性组织因子结合微粒的释放来调节凝血酶生成。
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