支原体脂多糖诱导人白细胞促凝血活性
Induction of procoagulant activity in human leukocytes with lipoglycans from mycoplasmas.
作者信息
Miragliotta G, Barone G, Monno R A, Fumarola D, Smith P F
出版信息
J Clin Microbiol. 1987 Jul;25(7):1295-7. doi: 10.1128/jcm.25.7.1295-1297.1987.
Lipoglycans from mycoplasmas possess the ability to induce the elaboration of procoagulant activity. This represents a third endotoxic property for these polymers, in addition to the pyrogenicity and clotting of Limulus lysate reported previously. Lipoglycans from three species of Acholeplasma (A. axanthum, A. granularum, and A. oculi) stimulated the elaboration in vitro of procoagulant activity by human mononuclear cells to differing extents. Two serotypes, 3 and 4, of Ureaplasma urealyticum also exhibited this stimulatory activity. The activities of lipoglycans tested were, in decreasing order, A. oculi greater than U. urealyticum type 4 greater than A. axanthum greater than U. urealyticum type 3 greater than A. granularum.
支原体的脂多糖具有诱导促凝血活性产生的能力。这是这些聚合物的第三种内毒素特性，此外还有先前报道的热原性和鲎试剂凝结反应。来自三种无胆甾原体（黄无胆甾原体、颗粒无胆甾原体和眼无胆甾原体）的脂多糖在体外不同程度地刺激人单核细胞产生促凝血活性。解脲脲原体的两种血清型，即3型和4型，也表现出这种刺激活性。所测试的脂多糖活性从高到低依次为：眼无胆甾原体＞解脲脲原体4型＞黄无胆甾原体＞解脲脲原体3型＞颗粒无胆甾原体。
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