Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2024 May;38(5):2448-2461. doi: 10.1002/ptr.8171. Epub 2024 Mar 3.
Resveratrol (RSV) has garnered significant attention in recent years due to its potential benefits against chronic diseases. However, its effects and safety in older adults have not been comprehensively studied. This study aimed to determine the effects and safety of RSV supplementation in older adults. MEDLINE/PubMed, Scopus, and Web of Science databases were comprehensively searched for eligible studies. Studies were enrolled if they were randomized clinical trials and had incorporated RSV supplementation for older adults. Two independent authors conducted the literature search, and eligibility was determined according to the PICOS framework. Study details, intervention specifics, and relevant outcomes were collected during the data collection. The Cochrane RoB-2 tool was used to evaluate the risk of bias. This review included 10 studies. The combination of RSV and exercise improved exercise adaptation and muscle function in healthy older adults and physical performance and mobility measures in individuals with functional limitations. RSV showed potential neuroprotective effects in patients with Alzheimer's disease. In overweight individuals, RSV demonstrated a positive impact on cognitive function, but it increased some biomarkers of cardiovascular disease risk at high doses. In older adults with diabetes and those with peripheral artery disease (PAD), RSV was not more effective than placebo. No study reported significant adverse events following RSV treatment. RSV can improve various health parameters in age-related health conditions. However, the optimal dosage, long-term effects, and potential interactions with medications still need to be investigated through well-designed RCTs.
白藜芦醇（RSV）由于其对慢性病的潜在益处，近年来受到了广泛关注。然而，其在老年人中的作用和安全性尚未得到全面研究。本研究旨在确定 RSV 补充剂对老年人的作用和安全性。综合检索了 MEDLINE/PubMed、Scopus 和 Web of Science 数据库中符合条件的研究。如果研究是随机临床试验，并纳入了 RSV 补充剂对老年人的干预，就符合纳入标准。两名独立的作者进行了文献检索，并根据 PICOS 框架确定了纳入标准。在数据收集过程中，收集了研究细节、干预措施的具体情况和相关结果。使用 Cochrane RoB-2 工具评估了偏倚风险。本综述纳入了 10 项研究。RSV 与运动的联合应用改善了健康老年人的运动适应和肌肉功能，以及功能受限个体的身体表现和移动能力测量值。RSV 对阿尔茨海默病患者有潜在的神经保护作用。在超重个体中，RSV 对认知功能有积极影响，但高剂量时会增加一些心血管疾病风险的生物标志物。在糖尿病和外周动脉疾病（PAD）的老年人中，RSV 并不比安慰剂更有效。没有研究报告 RSV 治疗后有明显的不良反应。RSV 可以改善与年龄相关的健康状况下的各种健康参数。然而，还需要通过精心设计的 RCT 来研究最佳剂量、长期效果以及与药物的潜在相互作用。
