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Increased oxidized low-density lipoprotein in mice exposed to a high-fat diet impaired spermatogenesis by inhibiting testosterone synthesis via the Klk1bs/Eid3 pathway.

作者信息

Yuan Chenfeng, Hong Hanhui, Wang Nan, Chen Tong, Cao Maosheng, Zhao Yun, Shen Caomeihui, Chen Xue, Luo Yuxin, Zhang Boqi, Zhou Xu, Li Chunjin

机构信息

College of Animal Sciences, Jilin University, Changchun, P. R. China.

College of Biological Sciences and Technology, Beijing Forestry University, Beijing, P. R. China.

出版信息

Clin Transl Med. 2024 Mar;14(3):e1603. doi: 10.1002/ctm2.1603.

DOI:10.1002/ctm2.1603
PMID:38433441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10909978/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/9fcc7e54b5e3/CTM2-14-e1603-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/0c38e15fbad4/CTM2-14-e1603-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/8da9ad997e89/CTM2-14-e1603-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/c8b7b19a93de/CTM2-14-e1603-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/9fcc7e54b5e3/CTM2-14-e1603-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/0c38e15fbad4/CTM2-14-e1603-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/8da9ad997e89/CTM2-14-e1603-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/c8b7b19a93de/CTM2-14-e1603-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4e/10909978/9fcc7e54b5e3/CTM2-14-e1603-g002.jpg

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本文引用的文献

1
Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.氧化型低密度脂蛋白通过影响睾丸间质细胞的线粒体功能和p38丝裂原活化蛋白激酶/环氧合酶-2信号通路来抑制睾酮的生物合成。
Cell Death Dis. 2020 Aug 14;11(8):626. doi: 10.1038/s41419-020-02751-z.
2
EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation.EID3是EID家族的一个新成员，也是CBP依赖的共激活的抑制剂。
Nucleic Acids Res. 2005 Jun 24;33(11):3561-9. doi: 10.1093/nar/gki667. Print 2005.
3
Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells.
心血管疾病中的性别差异：探索微生物群和免疫的作用。
Biomedicines. 2024 Jul 24;12(8):1645. doi: 10.3390/biomedicines12081645.
支持细胞中缺乏雄激素受体的雄性小鼠出现精子发生缺陷和低睾酮血症导致的不育。
Proc Natl Acad Sci U S A. 2004 May 4;101(18):6876-81. doi: 10.1073/pnas.0307306101. Epub 2004 Apr 23.
4
Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.小鼠睾丸间质细胞表达激肽释放酶21（Klk21），这是一种可切割纤连蛋白和胰岛素样生长因子结合蛋白3的组织激肽释放酶。
Endocrinology. 2001 Nov;142(11):4918-29. doi: 10.1210/endo.142.11.8505.
5
Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity.小鼠klk27的克隆与特性分析，klk27是一种在睾丸间质细胞中表达且具有类胰凝乳蛋白酶特异性的新型组织激肽释放酶。
Eur J Biochem. 2000 Dec;267(23):6858-65. doi: 10.1046/j.1432-1033.2000.01786.x.