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氧化铈纳米酶在氧化损伤相关疾病中的高级生物学应用

Advanced Biological Applications of Cerium Oxide Nanozymes in Disease Related to Oxidative Damage.

作者信息

Bai Yandong, Li Yongmei, Li Yuemei, Tian Lijie

机构信息

Tianjin Union Medical Center, No. 190 Jieyuan Road, Hongqiao District, Tianjin 300121, China.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, No. 6 Huanrui North Road, Ruijing Street, Beichen District, Tianjin 300134, China.

出版信息

ACS Omega. 2024 Feb 14;9(8):8601-8614. doi: 10.1021/acsomega.3c03661. eCollection 2024 Feb 27.

DOI:10.1021/acsomega.3c03661
PMID:38434816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10905716/
Abstract

Due to their excellent catalytic activities, cerium oxide nanoparticles have promise as biological nanoenzymes. A redox reaction occurs between Ce ions and Ce ions during which they undergo conversion by acquiring or losing electrons as well as forming oxygen vacancies (or defects) in the lattice structure, which can act as antioxidant enzymes and simulate various enzyme activities. A number of cerium oxide nanoparticles have been engineered with multienzyme activities, including catalase, superoxide oxidase, peroxidase, and oxidase mimetic properties. Cerium oxide nanoparticles have nitric oxide radical clearing and radical scavenging properties and have been widely used in a number of fields of biology, including biomedicine, disease diagnosis, and treatment. This review provides a comprehensive introduction to the catalytic mechanisms and multiple enzyme activities of cerium oxide nanoparticles, along with their potential applications in the treatment of diseases of the brain, bones, nerves, and blood vessels.

摘要

由于其出色的催化活性，氧化铈纳米颗粒有望成为生物纳米酶。铈离子之间会发生氧化还原反应，在此过程中，它们通过获得或失去电子以及在晶格结构中形成氧空位（或缺陷）来进行转化，这些氧空位（或缺陷）可以充当抗氧化酶并模拟各种酶的活性。许多氧化铈纳米颗粒已被设计成具有多种酶活性，包括过氧化氢酶、超氧化物氧化酶、过氧化物酶和氧化酶模拟特性。氧化铈纳米颗粒具有清除一氧化氮自由基和自由基的特性，已广泛应用于生物医学、疾病诊断和治疗等多个生物学领域。本综述全面介绍了氧化铈纳米颗粒的催化机制和多种酶活性，以及它们在治疗脑、骨、神经和血管疾病方面的潜在应用。

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