De Rosa C T, Stara J F, Durkin P R
Toxicol Ind Health. 1985 Dec;1(4):177-91. doi: 10.1177/074823378500100411.
During the past 3 years, EPA's ECAO/Cincinnati has developed a method to rank chemicals based on chronic toxicity data. This ranking system reflects two primary attributes of every chemical: the minimum effective dose and the type of effect elicited at that dose. The purpose for developing this chronic toxicity ranking system was to provide the EPA with the technical background required to adjust the RQs of hazardous substances designated in Section 101(14) of CERCLA or "Superfund." This approach may have applications to other areas of interest to the EPA and other regulatory agencies where ranking of chemicals based on chronic toxicity is desired.
在过去三年中，美国环境保护局（EPA）的环境化学评估办公室/辛辛那提分部开发了一种基于慢性毒性数据对化学品进行排名的方法。该排名系统反映了每种化学品的两个主要属性：最小有效剂量以及该剂量下引发的效应类型。开发这种慢性毒性排名系统的目的是为美国环境保护局提供调整《综合环境反应、赔偿和责任法》（CERCLA）或“超级基金”第101(14)节中指定的有害物质风险评估值（RQs）所需的技术背景。这种方法可能适用于美国环境保护局和其他监管机构感兴趣的其他领域，这些领域需要根据慢性毒性对化学品进行排名。
